Treatment of brain damage

• US 20030108535A1
• Filed: 01/14/2003
• Published: 06/12/2003
• Est. Priority Date: 03/29/1999
• Status: Active Grant

• Current Assignee: Helen Hodges
• Original Assignee: Helen Hodges
• Inventors: Hodges, Helen
• Granted Patent: US 7,247,298 B2
• Time in Patent Office: Days
• US Class Current: 424/93.21
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36

Abstract

The present invention relates to the treatment of brain damage by cellular transplantation. According to one aspect of the invention, a method for treating a motor, sensory and/or cognitive deficit comprises administering a composition comprising pluripotent cells into the damaged brain in a region contra-lateral to that containing the site of damage. The cells are preferably conditionally immortal.

Claims

1. A method for treating brain damage, comprising administering a composition comprising pluripotent cells into the damaged brain, wherein administration is into the brain hemisphere contra-lateral to that containing the site of damage.

2. The method, according to claim 1, wherein said cells are conditionally immortal.

3. The method, according to claim 1, wherein said cells are neuroepithelial stem cells.

4. The method, according to claim 1, wherein said cells are from the MHP36 clonal cell line.

5. The method, according to claim 1, wherein said brain damage is associated with stroke.

6. The method, according to claim 1, wherein said cells are co-administered to the ipsi-lateral brain hemisphere.

7. The method, according to claim 1, wherein the brain is stimulated by exercise after administering the composition.

8. The method, according to claim 7, wherein said exercise is augmented by bio-feedback.