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Whole cell assay systems for cell surface proteases

  • US 20030108978A1
  • Filed: 10/25/2002
  • Published: 06/12/2003
  • Est. Priority Date: 10/25/2001
  • Status: Active Grant
First Claim
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1. A method of assaying for the activity of an ADAM (a disintegrin and metalloprotease) in a whole cell system, comprising:

  • (a) selecting a soluble substrate that is specifically cleavable by the ADAM;

    (b) combining the soluble substrate with the whole cell system under conditions that allow processing of the substrate to a product by the ADAM; and

    (c) determining the amount of the product as an indication of the ADAM activity.

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