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Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells

  • US 20030109448A1
  • Filed: 11/07/2002
  • Published: 06/12/2003
  • Est. Priority Date: 11/07/2001
  • Status: Abandoned Application
First Claim
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1. A method for modulating the distribution of a polyamide within eukaryotic cells, the method comprising:

  • administering to the eukaryotic cells a molecular trafficking compound selected from the group consisting of P-glycoprotein inhibitors, ATPase affecting chemicals, pH or proton gradient disrupters, calcium channel blockers, ATP depleting chemicals, sodium/potassium channel blockers, MRP inhibitors, protein kinase inhibitors, Multidrug Resistance Compounds and combinations thereof, and administering the polyamide to the eukaryotic cells.

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