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Non-inclusion cyclodextrin complexes

  • US 20030109492A1
  • Filed: 10/18/2002
  • Published: 06/12/2003
  • Est. Priority Date: 10/18/2001
  • Status: Active Grant
First Claim
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1. A method for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water, said active ingredient being a drug, cosmetic additive, food additive or agrochemical, said method comprising combining said active ingredient with β

  • -cyclodextrin in an aqueous complexation medium, said medium comprising from about 0.1% to about 80% (weight/volume) of β

    -cyclodextrin and from about 0.1% to about 5% (weight/volume) of a negatively- or positively-charged compound which forms an inclusion or non-inclusion complex with β

    -cyclodextrin and its inclusion complexes, said charged compound being acceptable for use in a pharmaceutical, cosmetic, food or agricultural composition.

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