Transition metal mediated process
First Claim
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1. A method of making an optionally substituted 2-amino-benzoxazole or 2-amino-benzimidazole which comprises reacting a corresponding optionally substituted N-(2-hydroxyphenyl)thiourea or N-(2-aminophenyl)thiourea, respectively, with a transition metal in its I or II oxidation state, in the presence or absence of a base to obtain the optionally substituted 2-amino-benzoxazole or 2-aminobenzimidazole.
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Abstract
This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.
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Citations
16 Claims
- 1. A method of making an optionally substituted 2-amino-benzoxazole or 2-amino-benzimidazole which comprises reacting a corresponding optionally substituted N-(2-hydroxyphenyl)thiourea or N-(2-aminophenyl)thiourea, respectively, with a transition metal in its I or II oxidation state, in the presence or absence of a base to obtain the optionally substituted 2-amino-benzoxazole or 2-aminobenzimidazole.
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2. A process for the synthesis of a compound of formula (II),
- 3. A process for the synthesis of a compound of formula (II),
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5. A process for the synthesis of a compound of formula (II),
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9. A method of making an optionally substituted 2-amino-benzoxazole or 2-amino-benzimidazole which comprises reacting a corresponding optionally substituted N-(2-hydroxyphenyl)thiourea or N-(2-aminophenyl)thiourea, respectively, with a transition metal in its III oxidation state, in the presence or absence of a base to obtain the optionally substituted 2-amino-benzoxazole or 2-aminobenzimidazole.
- 10. A process for the synthesis of a compound of formula (II),
- 11. A process for the synthesis of a compound of formula (II),
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13. A process for the synthesis of a compound of formula (II),
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