Culture of sessile marine animals

• US 20030111020A1
• Filed: 01/31/2003
• Published: 06/19/2003
• Est. Priority Date: 05/05/1998
• Status: Active Grant

• Current Assignee: Pharma Mar, S.A.
• Original Assignee: Pharma Mar, S.A.
• Inventors: Garcia, Carlos Barbero, Targotay, Bullent Kukurtcu, Benitez, Silvia Martin, Lozano, Santiago Naranjo
• Granted Patent: US 6,712,023 B2
• Time in Patent Office: Days
• US Class Current: 119/200
• CPC Class Codes: A01K 61/54 of bivalves, e.g. oysters or mussels
• CPC Class Codes: A01K 67/033 Rearing or breeding invertebrates; New breeds of invertebrates
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: Y02A 40/81 Aquaculture, e.g. of fish

Abstract

Sessile marine organisms are a source of many marine pharmaceuticals. A method of producing such a marine pharmaceutical is provided which involves positioning a plurality of like substrates in sea water, growing the organism on the plurality of substrates, harvesting the grown organism, and extracting the pharmaceutical from the harvested organism.

Claims

1. A method of producing a marine pharmaceutical by extraction from a sessile marine organism, which method comprises positioning a plurality of like substrates in sea water, growing the organism on the plurality of substrates, harvesting the grown organism, and extracting the pharmaceutical from the harvested organism.

2. A method according to claim 1, wherein the marine organism is Ecteinascidia turbinata and the marine pharmaceutical is an ecteinascidin compound.

3. A method according to claim 1, wherein the marine organism is Aplidium albicans, and the marine pharmaceutical is a didemnin compound.

4. A method of farming a sessile marine organism intended for extraction of a marine pharmaceutical, which method comprises positioning a plurality of like substrates in sea water, allowing larvae from a colony of the organism to seed the substrates, growing the organism on the plurality of substrates, and harvesting the grown organism.

5. A method according to claim 4, wherein the substrates are placed adjacent the colony.

6. A method according to claim 4, wherein at least one collector comprising a support with substrates is placed adjacent the colony to collect larvae.

7. A method according to claim 6, wherein the collector is transferred to another site for growth of the organism.

8. A method of farming a sessile marine organism intended for extraction of a marine pharmaceutical, which method comprises positioning a plurality of like substrates in sea water, transplanting the organism onto the substrates, growing the organism on the plurality of substrates, and harvesting the grown organism.

9. A method according to claim 8, wherein individual organisms are transplanted onto the substrates.

10. A method according to claim 8, wherein fragments of organisms are transplanted onto the substrates.

11. A method according to any of claims 8 to 10, wherein the substrates are provided by cables, ropes, meshes, nets, rods, planks, cages, and baskets for direct fixing of the organism.

12. A method according to any of claims 8 to 11, wherein submerged structures comprising the substrates are maintained between bottom anchorage devices and flotation devices.

13. A method according to any of claims 8 to 11, wherein submerged structures comprising the substrates are maintained between sides of a natural or artificial basin.

14. A device for culturing of sessile marine organisms which comprises a support frame and flotation structure, attachment guides, substrates for securing to the attachment guides, a fixation and anchorage system, and optionally a shade.

15. A device for growing sessile marine organisms on substrates, comprising arrays of vertically extending substrates each attached to a respective one of an array of horizontal attachment guides secured to and supported by a support flotation frame provided with an anchoring system or a mooring system, and optionally having a shade to reduce light incident on the substrates.

16. A device for growing sessile marine organisms on substrates, comprising arrays of substrates forming an attachment and growth structure secured to a support flotation system provided with an anchoring system or a mooring system.

17. A method of growing Ecteinascidia turbinata by transplanting fragments of colonies of the organism to a substrate using as substrate and support a device comprising of lengths of an approximately 0.5 to 4 m wide plastic mesh with holes between 2 and 8 cm kept entirely submerged by anchorage to the bottom of a shallow coastal lagoon and held approximately vertically by floatation devices.

18. A method of capturing Ecteinascidia turbinata larvae onto 0.2-2 m lengths of ropes or wooden rods using a device comprising of a floating frame, approximately 1-2 m by 3-6 m with a shade onto which the ropes or wooden rods are affixed and maintained horizontally or vertically submerged in the water in proximity to colonies of the organism until larvae attach to them so that adult colonies can later be grown from these ropes or rods so seeded.

19. A method of growing Ecteinascidia turbinata by implanting fragments of colonies onto 0.2-2 m lengths of ropes or wooden rods using a device comprising of a floating frame, approximately 1-2 m by 3-6 m with a shade from which the ropes or wooden rods with attached colonies can hang vertically submerged in water for growth of the organism.