Methods and compositions for pulmonary delivery of insulin
First Claim
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1. A method for aerosolizing a dose of insulin, said method comprising:
- providing insulin as a dry powder;
dispersing an amount of the dry powder in a gas stream to form an aerosol; and
capturing the aerosol in a chamber having a mouthpiece for subsequent inhalation by a patient.
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Abstract
Systemic delivery of insulin to a mammalian host is accomplished by inhalation of a dry powder of insulin. It has been found that dry insulin powders are rapidly absorbed through the alveolar regions of the lungs.
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Citations
25 Claims
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1. A method for aerosolizing a dose of insulin, said method comprising:
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providing insulin as a dry powder;
dispersing an amount of the dry powder in a gas stream to form an aerosol; and
capturing the aerosol in a chamber having a mouthpiece for subsequent inhalation by a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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- 8. An improved method for the respiratory delivery of insulin, wherein the improvement comprises delivering the insulin as a dry powder.
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15. A method for preparing a stable, dry powder insulin composition, said method comprising:
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dissolving insulin in an aqueous buffer to form a solution; and
spray drying the solution to produce substantially amorphous particles having an average size below 10 μ
m. - View Dependent Claims (16, 17, 18, 19, 24)
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- 20. An insulin composition for pulmonary delivery, said composition comprising individual particles which include insulin present at from 5% to 99% by weight in a pharmaceutical carrier material and have a size below 10 μ
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25. An insulin composition consisting essentially of dry powder insulin having an average particle size below 10 μ
- m.
Specification