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Method for enabling delivery of an active agent

  • US 20030113370A1
  • Filed: 12/02/2002
  • Published: 06/19/2003
  • Est. Priority Date: 03/04/1999
  • Status: Active Grant
First Claim
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1. A method for enabling delivery of an active agent, said method comprising the steps of:

  • preparing doses of the active agent by the steps of;

    providing an active retinoid agent having low aqueous solubility;

    dissolving the active agent in a vehicle in order to eliminate initial active agent dissolution within a gastrointestinal tract;

    incorporating an emulsifier into the vehicle in order to promote subsequent self-emulsification of the active agent and vehicle in the gastrointestinal tract; and

    encapsulating the active agent, vehicle and emulsifier with a capsule shell formulated to open upon ingestion into said gastrointestinal tract;

    distributing educational materials to medical office personnel including prescribers who are qualified to prescribe the doses for patients, said educational materials including information as to what the patients need to know and what the patients must do in order to both avoid adverse side effects while taking the doses and to receive a prescription for the doses; and

    providing guidelines for counseling the patients with regard to what the patients need to know and what the patients must do in order to both avoid the adverse side effect while taking the dose and to receive prescriptions for the doses.

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