Implantable, retrievable sensors and immunosensors
First Claim
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1. An analyte detector for implantation within a blood vessel, comprising:
- a support, having a first side for contacting the wall of the vessel and a second side for facing radially inwardly toward the center of the vessel; and
a sensor located on the support and having a sensing surface thereon;
wherein the sensing surface is configured such that the velocity of blood in the vessel inhibits obstruction of the sensing surface; and
a snareable member connected to the sensor or the support, wherein the snareable member is configured to allow for removal of the sensor in a catheterization procedure.
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Abstract
A sensor is disclosed, for implantation within a blood vessel to monitor an analyte in blood. In one embodiment, the sensor is retrievable. In another embodiment, the sensor is an immunosensor. A signal representative of a reaction between an analyte and an antigen of the analyte is transmitted to an external receiver. Methods are also disclosed.
215 Citations
47 Claims
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1. An analyte detector for implantation within a blood vessel, comprising:
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a support, having a first side for contacting the wall of the vessel and a second side for facing radially inwardly toward the center of the vessel; and
a sensor located on the support and having a sensing surface thereon;
wherein the sensing surface is configured such that the velocity of blood in the vessel inhibits obstruction of the sensing surface; and
a snareable member connected to the sensor or the support, wherein the snareable member is configured to allow for removal of the sensor in a catheterization procedure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 23, 24, 25, 26)
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17. An implantable sensor for sensing the presence of an analyte in a vessel, comprising:
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a tubular support structure for anchoring the sensor in the vessel, the support structure having a side wall with a luminal side facing toward the center of the vessel and an abluminal side facing toward the wall of the vessel;
a sensor housing carried by the support, the housing having an exterior configuration to minimize blood flow turbulence;
a power supply and electrical circuitry in the housing;
a sensing surface exposed to the exterior of the housing; and
a connector connected to the sensor housing or the support, wherein the connector is configured to allow for removal of the sensor housing in a catheterization procedure. - View Dependent Claims (18, 19, 20, 21, 22)
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- 27. A method of using a sensor in a blood vessel, comprising the steps of providing a sensor having an analyte sensing surface thereon and positioning the sensor at a site in a blood vessel such that the sensing surface is positioned radially inwardly from the vessel wall by a sufficient distance that the blood flow shear rate at the sensing surface substantially delays obstruction of the sensing surface, and removing the sensor during a catheterization process.
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33. An analyte detector for implantation within a blood vessel, comprising:
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a support, having a first side for contacting the wall of the vessel and a second side for facing radially inwardly toward the center of the vessel; and
a sensor carried by the support;
wherein the sensor produces an electrical signal representative of a reaction between an analyte and an antigen. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40)
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- 41. A method of detecting an analyte in a blood vessel, comprising the steps of providing a sensor carried between at least two supports and positioning the sensor at a site in a blood vessel such that the sensing surface is positioned so that the blood flow shear rate at the sensing surface substantially delays obstruction of the sensing surface, and producing an electric signal representative of a reaction between an analyte and an antigen.
Specification