Osmotic delivery system flow modulator apparatus and method
First Claim
1. An osmotic delivery system comprising:
- an enclosure having an opening and an interior for holding a liquid swellable osmotic agent and a beneficial agent, the enclosure provided with a semipermeable portion, the liquid swellable osmotic agent for imbibing liquid from a surrounding environment through the semipermeable portion and causing a delivery rate of the beneficial agent from the enclosure;
an osmotic delivery system flow modulator assembly having a flow modulator body at least partially positioned in the opening of the enclosure, the body having two opposing ends and means for venting the osmotic delivery system when the beneficial agent is inserted into the osmotic delivery system; and
a delivery path located separate from the venting means for delivering the beneficial agent from the osmotic delivery system, the delivery path being formed in at least one of the enclosure and the flow modulator assembly.
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Accused Products
Abstract
An osmotic delivery system flow modulator assembly, an osmotic delivery system with a flow modulator assembly, and a method of assembling an osmotic delivery system. The osmotic delivery system flow modular assembly includes a body having a hole located through the body and communicating two opposing ends of the body. The use of the osmotic delivery system flow modulator assembly lessens the chance that air or gas pockets will form in the enclosure of the osmotic delivery system during assembly of the system. Because less air is within the osmotic delivery system, performance of the system is enhanced. Use of the flow modulator assembly also lessens the chance that beneficial agent will be wasted during assembly of the osmotic delivery system.
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Citations
55 Claims
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1. An osmotic delivery system comprising:
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an enclosure having an opening and an interior for holding a liquid swellable osmotic agent and a beneficial agent, the enclosure provided with a semipermeable portion, the liquid swellable osmotic agent for imbibing liquid from a surrounding environment through the semipermeable portion and causing a delivery rate of the beneficial agent from the enclosure;
an osmotic delivery system flow modulator assembly having a flow modulator body at least partially positioned in the opening of the enclosure, the body having two opposing ends and means for venting the osmotic delivery system when the beneficial agent is inserted into the osmotic delivery system; and
a delivery path located separate from the venting means for delivering the beneficial agent from the osmotic delivery system, the delivery path being formed in at least one of the enclosure and the flow modulator assembly. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An osmotic delivery system flow modulator assembly comprising:
an osmotic delivery system flow modulator body constructed and arranged for at least partial positioning in an opening of an enclosure of an osmotic delivery system, the body having two opposing ends, a vent hole located through the body, the vent hole communicating the opposing ends, and a delivery path formed in the body, located separate from the vent hole, and for delivering a beneficial agent from the osmotic delivery system. - View Dependent Claims (18, 19, 20, 21)
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22. An osmotic delivery system flow modulator assembly comprising:
a flow modulator body constructed and arranged for at least partial positioning in an opening of an enclosure of an osmotic delivery system, the body including two opposing ends, a first hole located through the body, a second hole located through the body, the first hole and the second hole each communicating the opposing ends, and a delivery path for delivering a beneficial agent from the osmotic delivery system, the flow modulator assembly including means for sealing at least one of the first and second holes. - View Dependent Claims (23, 24, 25, 26, 27)
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28. An osmotic delivery system comprising:
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an enclosure having an opening and an interior for holding a liquid swellable osmotic agent and a beneficial agent, the enclosure provided with a semipermeable portion, the liquid swellable osmotic agent for imbibing liquid from a surrounding environment through the semipermeable portion and causing a delivery rate of the beneficial agent from the enclosure;
an osmotic delivery system flow modulator assembly having a, flow modulator body at least partially positioned in the opening of the enclosure, the body having two opposing ends, a first hole located through the body, and a second hole located through the body, the first and second holes each communicating the opposing ends, the flow modulator assembly including at least one cap positioned in one of the first and second holes, at least one of the flow modulator assembly and the enclosure including a delivery path for delivering a beneficial agent from the osmotic agent delivery system. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35)
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36. An osmotic delivery system flow modulator assembly comprising:
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a flow modulator body constructed and arranged for at least partial positioning in an opening of an enclosure of an osmotic delivery system, the body including two opposing ends, a hole located through the body, communicating the opposing ends, and a delivery path for delivering a beneficial agent from an osmotic delivery system;
a stopper having a head, a shaft, and a tip located opposite from the head, the stopper being at least partially positioned in the hole to seal the hole; and
a partition secured to the body with the stopper so that the partition is secured between the body and the head of the stopper.
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37. An osmotic delivery system comprising:
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an enclosure having an opening and an interior for holding a liquid swellable osmotic agent and a beneficial agent, the enclosure provided with a semipermeable portion, the liquid swellable osmotic agent for imbibing liquid from a surrounding environment through the semipermeable portion and causing a delivery rate of the beneficial agent from the enclosure;
an osmotic delivery system flow modulator assembly having a flow modulator body at least partially positioned in the opening of the enclosure, the body having two opposing ends, and a hole located through the body communicating the opposing ends;
a delivery path located separate from the hole and formed in at least one of the flow modulator assembly and the enclosure for delivering the beneficial agent from the osmotic delivery system; and
means for substantially preventing a liquid external of the osmotic delivery system from entering the interior of the osmotic delivery system, the preventing means allowing the beneficial agent to exit the osmotic delivery system to the surrounding environment. - View Dependent Claims (38, 39, 40)
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41. A method of assembling an osmotic delivery system having an enclosure, the enclosure having an opening, and the osmotic delivery system having a semipermeable portion, the method comprising the steps of:
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positioning an osmotic Agent in an interior of the enclosure;
inserting an osmotic delivery system flow modulator body at least partially in the opening of the enclosure to at least partially seal the opening; and
delivering a beneficial agent into the enclosure through a fill hole in the flow modulator body. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48)
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49. A method of delivering a beneficial agent into an osmotic delivery system, comprising the steps of:
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inserting the beneficial agent through a hole in a flow modulator body inserted in an opening of the osmotic delivery system; and
venting gas from the osmotic delivery system through the hole while inserting the beneficial agent through the hole. - View Dependent Claims (50, 51)
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52. A method of assembling an osmotic delivery system having an enclosure, the enclosure having an opening, and the osmotic delivery system having a semipermeable portion, comprising the steps of:
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positioning an osmotic agent into an interior of the enclosure;
inserting an osmotic delivery system flow modulator body at least partially in the opening of the enclosure;
delivering a beneficial agent into the enclosure through the hole in the flow modulator body; and
creating a vacuum adjacent to the flow modulator body to reduce an amount of gas within the osmotic delivery system. - View Dependent Claims (53, 54, 55)
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Specification