Proteomic analysis of tumors for development of consultative report of therapeutic options
First Claim
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1. A method of identifying at least one potential therapeutic option for treatment of a tumor comprising the steps of:
- correlating a cluster of protein expression for a proteomic profile of said tumor to at least one molecular pathway of said tumor; and
identifying at least one potential therapeutic option based upon said molecular pathway identified.
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Abstract
The present invention provides methods of identifying potential therapeutic options for treatment of a tumor, and a consultative report providing the same.
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Citations
29 Claims
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1. A method of identifying at least one potential therapeutic option for treatment of a tumor comprising the steps of:
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correlating a cluster of protein expression for a proteomic profile of said tumor to at least one molecular pathway of said tumor; and
identifying at least one potential therapeutic option based upon said molecular pathway identified. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of identifying at least one potential therapeutic option for treatment of a tumor comprising the steps of:
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correlating a cluster of protein expression for a proteomic profile comprising an immunohistochemical or immunofluorescent analysis of said tumor to at least one physiological pathway of said tumor, wherein said immunohistochemical or immunofluorescent analysis comprises using a panel of at least five antibodies directed to different biological targets selected from the group consisting of Her-2/neu, Ki-67, p53, Cyclin D1, c-Jun, ER, PR, gp130, IL-6, IL-11, EGFR, TGF-α
, farnesyl transferase, p21ras, the latency-associated peptide of TGF-β
1, TGF-β
RII, bcl-2, and COX-2 in said tumor; and
identifying at least one potential therapeutic option based upon said physiological pathway identified.
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12. A method of generating a consultative report that identifies at least one potential therapeutic option for treatment of a tumor from a patient comprising the steps of:
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listing at least one molecular pathway identified as being a part of the pathology for said tumor from said patient; and
listing at least one pharmaceutical agent that is directed to a biological target involved in said molecular pathway identified. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification