Liposomes containing active substances

• US 20030124180A1
• Filed: 10/31/2002
• Published: 07/03/2003
• Est. Priority Date: 05/02/2000
• Status: Abandoned Application

• Current Assignee: PharmaCept GmbH (Magle Chemoswed Holding AB)
• Original Assignee: PharmaCept GmbH (Magle Chemoswed Holding AB)
• Inventors: Berger, Gerd, Ebert, Jurgen
• Application Number:
  US10/258,997
• Publication Number:
  US 20030124180A1
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623

Abstract

Active ingredients encapsulated in liposomes which are characterized in that the active ingredient(s) are encapsulated in a proportion of from 1% by weight to 90% by weight based on the amount of active ingredient employed are claimed. These active ingredients are suitable in particular for the treatment of tumors, as food supplements, for producing contrast agents for imaging methods and for producing diagnostic agents for diseases.

Claims

1. An active ingredient encapsulated in liposomes which is characterized in that it is encapsulated in a proportion of from 1% by weight to 90% by weight based on the amount of active ingredient employed.

2. An active ingredient encapsulated in liposomes as claimed in claim 1, characterized in that the active ingredient is encapsulated in a proportion of from 5 to 85% by weight based on the amount of active ingredient employed.

3. An active ingredient encapsulated in liposomes as claimed in either of claims 1 or 2, characterized in that the active ingredient is selected from medicaments and pharmacologically active substances, nutrients, cosmetic substances, diagnostic substances and contrast agents for imaging methods.

4. An active ingredient encapsulated in liposomes as claimed in any of claims 1 to 3, characterized in that the liposomes are formed from phospholipids and, where appropriate, cholesterol and cholesterol derivatives and/or one or more hydrophilic, lipophilic or amphiphilic component(s).

5. An active ingredient encapsulated in liposomes as claimed in claim 4, characterized in that the phospholipid is selected from phosphatidylcholine (PC), distearoylphosphatidylcholine (DSPC), soybean phosphatidylcholine (soya-PC), hydrogenated soybean phosphatidylcholine (HSPC), egg phosphatidylcholine (egg PC), hydrogenated egg phosphatidylcholine (HEPC), dipalmitoylphosphatidylcholine (DPPC), dimyristoylphosphatidylcholine (DMPC) and any mixtures thereof.

6. The use of the active ingredient encapsulated in liposomes as claimed in any of claims 1 to 5 for producing a medicament for the treatment of tumors.

7. The use as claimed in claim 6, characterized in that the active ingredient is employed in combination with a pharmaceutical carrier, in particular with microspheres which are preferably prepared from polysacharides or polysacharide derivatives and are particularly preferably degradable.

8. The use of the active ingredient encapsulated in liposomes as claimed in any of claims 1 to 5 as food supplement.

9. The use of the active ingredient encapsulated in liposomes as claimed in any of claims 1 to 5 for producing a contrast agent for imaging methods.

10. The use of the active ingredient encapsulated in liposomes as claimed in any of claims 1 to 5 for producing a diagnostic agent for diseases.