Methods and apparatus for effectuating a lasting change in a neural-function of a patient

• US 20030125786A1
• Filed: 09/27/2002
• Published: 07/03/2003
• Est. Priority Date: 07/13/2000
• Status: Abandoned Application

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Inventors: Fowler, Brad, Firlik, Andrew D., Gliner, Bradford Evan, Levy, Alan J., Balzer, Jeffrey
• Application Number:
  US10/260,227
• Publication Number:
  US 20030125786A1
• Time in Patent Office: Days
• US Class Current: 607/116
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

Claims

1. An implantable electrode assembly, comprising:

an implantable medium having a flexible body that is configurable between a first shape for insertion through a hole in the patient and a second shape different than the first shape to cover a surface area on a patient having a different size than the hole; and

a plurality of electrodes carried by the flexible body, the electrodes being independently operable.

2. The implantable electrode assembly of claim 1 wherein the flexible body is in a compressed state in the first shape and an expanded state in the second shape.

3. The implantable electrode assembly of claim 2 wherein the flexible body comprises a foam sheet.

4. The implantable electrode assembly of claim 1 wherein the flexible body comprises an inflatable bladder which can be filled to move from the first state to the second state.

5. The implantable electrode assembly of claim 4 wherein the bladder is filled with a pressurized fluid.

6. The implantable electrode assembly of claim 1 wherein the flexible body comprises a rolled sheet in the first shape and unfurled sheet in the second shape.

7. The implantable electrode assembly of claim 1 wherein:

the electrode assembly further comprises a mechanical actuator in the flexible body that moves the flexible body from the first shape to the second shape; and

the flexible body covers the mechanical actuator.

8. The implantable electrode assembly of claim 1 wherein:

the electrode assembly further comprises a mechanical actuator in the flexible body that moves the flexible body from the first shape to the second shape, and the mechanical actuator comprises a plurality of fingers and a driver coupled to the fingers that moves the fingers between a contracted configuration to position the flexible body in the first shape and an expanded configuration to position the flexible body in the second shape;

the flexible body comprises a sheath that covers the fingers of the mechanical actuator; and

the electrodes are carried by the sheath.

9. The implantable electrode assembly of claim 1 wherein:

the electrode assembly further comprises a mechanical actuator in the flexible body that moves the flexible body from the first shape to the second shape, and the mechanical actuator comprises a shape memory filament that has an insertion configuration at an external temperature outside of the patient and a deployed configuration at approximately the body temperature of the patient;

the flexible body comprises a sheath that covers at least a portion of the shape memory filament; and

the electrodes are carried by the sheath.

10. The implantable electrode assembly of claim 9 wherein the shape memory filament comprises a nitinol strand.

11. The implantable electrode assembly of claim 9 wherein the shape memory filament comprises a nitinol strand that is substantially straight in the first shape and curved in the second shape.

12. The implantable electrode assembly of claim 11 wherein the shape memory filament is a spiral in the second shape.

13. An implantable electrode assembly, comprising:

a flexible support member having a first configuration for insertion through a hole in the patient and a second configuration for covering a portion of a cortical surface of the patient; and

a plurality of electrodes carried by the support member.

14. The implantable electrode assembly of claim 13 wherein the flexible support member comprises a compressible member that is in a compressed state in the first configuration and an expanded state in the second configuration.

15. The implantable electrode assembly of claim 13 wherein the flexible support member comprises an inflatable bladder which can be filled with a pressurized fluid to move from the first configuration to the second configuration.

16. The implantable electrode assembly of claim 13 wherein the flexible support member comprises a rolled sheet in the first configuration and unfurled sheet in the second configuration.

17. The implantable electrode assembly of claim 13 wherein:

the electrode assembly further comprises a mechanical actuator in the flexible support member that moves the flexible support member from the first configuration to the second configuration; and

the flexible support member covers the mechanical actuator.

18. The implantable electrode assembly of claim 13 wherein:

the electrode assembly further comprises a mechanical actuator in the flexible support member that moves the flexible support member from the first configuration to the second configuration, and the mechanical actuator comprises a plurality of fingers and a driver coupled to the fingers that moves the fingers between a contracted configuration to position the flexible support member in the first configuration and an expanded configuration to position the flexible support member in the second configuration;

the flexible support member comprises a sheath that covers the fingers of the mechanical actuator; and

the electrodes are carried by the sheath.

19. The implantable electrode assembly of claim 13 wherein:

the electrode assembly further comprises a mechanical actuator in the flexible support member that moves the flexible support member from the first configuration to the second configuration, and the mechanical actuator comprises a shape memory filament that has an insertion configuration at an external temperature outside of the patient and a deployed configuration at approximately a body temperature of the patient;

the flexible support member comprises a sheath that covers at least a portion of the shape memory filament; and

the electrodes are carried by the sheath.

20. The implantable electrode assembly of claim 19 wherein the shape memory filament comprises a nitinol strand.

21. The implantable electrode assembly of claim 19 wherein the shape memory filament comprises a nitinol strand that is substantially straight in the first configuration and curved in the second configuration.

22. An implantable electrode assembly, comprising:

an expandable support member having a flexible body; and

a plurality of electrodes carried by the support member.

23. The implantable electrode assembly of claim 22 wherein the flexible body comprises a foam that is in a compressed state in a first configuration and an expanded state in a second configuration.

24. The implantable electrode assembly of claim 22 wherein the flexible body comprises an inflatable bladder which can be filled with a pressurized fluid to move from a first configuration to a second configuration.

25. The implantable electrode assembly of claim 22 wherein the flexible body comprises a rolled sheet in a first configuration and unfurled sheet in a second configuration.

26. The implantable electrode assembly of claim 22 wherein:

the electrode assembly further comprises a mechanical actuator in the flexible body that moves the flexible body from a first configuration to a second configuration; and

the flexible body covers the mechanical actuator.

27. The implantable electrode assembly of claim 22 wherein:

the electrode assembly further comprises a mechanical actuator in the flexible body that moves the flexible body from a first configuration to a second configuration;

the flexible body comprises a sheath that covers at least a portion of the mechanical actuator; and

the electrodes are carried by the sheath.

28. A method of stimulating a brain of a patient for effectuating a neural function comprising:

positioning an electrode assembly in a first configuration proximate to a cortical region of the brain;

reconfiguring the electrode assembly to have a second configuration different than the first configuration; and

applying an electrical stimulation to the cortical region of the brain through the electrode assembly.

29. The method of claim 28 wherein positioning the electrode assembly in a first configuration comprises inserting the electrode assembly through a hole in the patient in a first shape and reconfiguring the electrode assembly to have a second configuration comprises expanding the electrode assembly to have a second shape different than the first shape.

30. The method of claim 29 wherein the second shape is larger than the first shape.

31. The method of claim 29 wherein the electrode assembly comprises a flexible implantable medium and at least one electrode, and the first shape comprises a compressed configuration and the second shape comprises an expanded configuration.

32. The method of claim 29 wherein the electrode assembly comprises a flexible implantable medium defined by a foam sheet and at least one electrode, and the first shape comprises a compressed configuration and the second shape comprises an expanded configuration.

33. The method of claim 29 wherein the electrode assembly comprises a flexible implantable medium defined by a dielectric sheet and at least one electrode, and the first shape comprises a roll-up configuration and the second shape comprises an unfurled configuration.

34. The method of claim 28 wherein the electrode assembly comprises a flexible implantable medium defined by an inflatable bladder and at least one electrode, and the inflatable bladder moves between the first shape and the second shape.

35. A method of electrically stimulating a region of a brain of a patient, comprising:

inserting an electrode assembly into the patient while the electrode assembly is in an insertion configuration;

altering the electrode assembly to be in a treatment configuration different than the insertion configuration after inserting the electrode assembly into the patient; and

applying electrical pulses to the brain through the electrode assembly.

36. The method of claim 35 wherein applying electrical pulses to the brain occurs while the electrode assembly is in the treatment configuration.

37. The method of claim 35 wherein the insertion configuration has a first shape with first surface area and the treatment configuration has a second shape with a second surface area larger than the first surface area.

38. The method of claim 35 wherein the electrode assembly comprises a flexible implantable medium and at least one electrode carried by the medium, and the insertion configuration comprises a compressed configuration and the treatment configuration comprises an expanded configuration.

39. The method of claim 35 wherein the electrode assembly comprises a flexible implantable medium defined by a foam sheet and at least one electrode carried by the foam sheet, and the insertion configuration comprises a compressed configuration and the treatment configuration comprises an expanded configuration.

40. The method of claim 35 wherein the electrode assembly comprises a flexible implantable medium defined by a dielectric sheet and at least one electrode carried by the sheet, and the insertion configuration comprises a rolled-up configuration and the treatment configuration comprises an unfurled configuration.