Multiple pulse extended release formulations of clindamycin
First Claim
1. An extended release composition, comprising a first fraction of clindamycin released in a first pulse, within about thirty minutes of oral administration of the composition to a subject, and a second fraction of clindamycin released in a second pulse, about 4 hours to about 15 hours after oral administration of the composition to the subject.
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Abstract
The present invention is directed to an oral dosage form for multiple-pulsed delivery of at least two fractions of clindamycin to a subject, one in an immediate-release form and the other in an extended release form. The oral dosage forms of the present invention provide a means for treating or preventing gram-positive bacterial infections with a minimal number of treatments per day, potentially, as little as once or twice per day.
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Citations
33 Claims
- 1. An extended release composition, comprising a first fraction of clindamycin released in a first pulse, within about thirty minutes of oral administration of the composition to a subject, and a second fraction of clindamycin released in a second pulse, about 4 hours to about 15 hours after oral administration of the composition to the subject.
- 19. An extended release composition, comprising a first fraction of clindamycin HCl released in a first pulse, within about thirty minutes of oral administration of the composition to a subject, and a second fraction of clindamycin HCl released at least 12 hours after oral administration to the subject.
Specification