Two-phase, water-absorbent bioadhesive composition
First Claim
1. A bioadhesive composition comprising a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase comprises a crosslinked hydrophobic polymer composition and the hydrophilic phase comprises a mixture of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionically bonding, or covalently
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Abstract
An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.
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Citations
29 Claims
- 1. A bioadhesive composition comprising a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase comprises a crosslinked hydrophobic polymer composition and the hydrophilic phase comprises a mixture of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionically bonding, or covalently
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23. A method for preparing a two-phase, water-absorbent bioadhesive composition comprising:
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(a) preparing a crosslinkable hydrophobic composition comprised of a hydrophobic polymer and at least one agent effective to crosslink the polymer; and
(b) preparing a hydrophilic composition comprised of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding;
(c) admixing the crosslinkable hydrophobic composition with the hydrophilic composition; and
(d) crosslinking the hydrophobic polymer in the admixture. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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Specification