Open-celled substrates for drug delivery
First Claim
1. A method of delivering a drug to a mammal through an inhalation route comprising heating a composition to form a thermal vapor, which is inhaled by the mammal, wherein the composition comprises a drug, and wherein the composition is coated onto a substrate, and wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells.
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Accused Products
Abstract
The present invention relates to the delivery of drugs through an inhalation route. Specifically, it relates to the formation of drug thermal vapors from a heated open-celled substrate for use in inhalation therapy. In a method aspect of the present invention, a method of delivering a drug to a mammal through an inhalation route is provided which comprises heating a composition to form a thermal vapor, which is inhaled by the mammal, wherein the composition comprises a drug, and wherein the composition is coated onto a substrate, and wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells. In a device aspect of the present invention, a device for delivering a drug to a mammal through an inhalation route is provided, wherein the device comprises: a power source; a substrate, wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells; and, an element permitting the mammal to inhale the thermal vapor. In a kit aspect of the present invention, a kit for delivering a drug to a mammal through an inhalation route is provided which comprises: a) a composition comprising a drug; and b) a device that forms a drug thermal vapor from the composition for inhalation by the mammal, wherein the device comprises a substrate, and wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells.
103 Citations
14 Claims
- 1. A method of delivering a drug to a mammal through an inhalation route comprising heating a composition to form a thermal vapor, which is inhaled by the mammal, wherein the composition comprises a drug, and wherein the composition is coated onto a substrate, and wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells.
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7. A device for delivering a drug to a mammal through an inhalation route, wherein the device comprises:
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a) a power source;
b) a substrate connected to the power source, wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells; and
c) an element permitting the mammal to inhale the thermal vapor. - View Dependent Claims (8, 9, 10)
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11. A kit for delivering a drug to a mammal through an inhalation route, wherein the kit comprises:
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a) a composition comprising a drug; and
b) a device that forms a drug thermal vapor from the composition for inhalation by the mammal, wherein the device comprises a substrate, and wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells. - View Dependent Claims (12, 13, 14)
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Specification