Methods for initiating in situ formation of hydrogels

• US 20030134032A1
• Filed: 11/15/2002
• Published: 07/17/2003
• Est. Priority Date: 11/16/2001
• Status: Abandoned Application

• Current Assignee: BioCure, Inc.
• Original Assignee: BioCure, Inc.
• Inventors: Chaouk, Hassan, Asfaw, Bruktawit
• Application Number:
  US10/295,817
• Publication Number:
  US 20030134032A1
• Time in Patent Office: Days
• US Class Current: 427/2.24
• CPC Class Codes: A61K 49/0457 Semi-solid forms, ointments, gels, hydrogels
• CPC Class Codes: A61L 24/0031 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

Methods for initiating formation of hydrogels in situ from a gellable composition and an initiator where the initiator is provided as a solid article or is contained in a solution infused to the intended site of formation of the hydrogel.

Claims

1. A method of initiating formation of a hydrogel in situ comprising the steps:

delivering a solid article comprising an initiator to the intended site of formation of the hydrogel; and

delivering a gellable composition that will form a hydrogel in response to the initiator to the intended site of formation of the hydrogel;

whereby the gellable composition forms the hydrogel.

2. The method of claim 1, wherein the solid article comprises microspheres.

3. The method of claim 1, wherein the solid article comprises a solid embolic device.

4. The method of claim 1, wherein the solid article is delivered to the site of intended formation of the hydrogel before the gellable composition is delivered to the site.

5. The method of claim 1, wherein the solid article is the tip of a catheter.

10. The method of claim 1, wherein the gellable composition comprises macromers having crosslinkable groups that are crosslinkable via free radical polymerization.

11. The method of claim 10, wherein the crosslinkable groups are olefinically unsaturated groups.

12. The method of claim 10, wherein the free radical polymerization is redox initiated.

13. The method of claim 12, wherein the redox initiation is performed via an oxidant and a reductant and one of the oxidant or reductant is the initiator.

6. A method of initiating formation of a hydrogel comprising the steps:

delivering a gellable composition that can form a hydrogel in response to an initiator to the intended site of formation of the hydrogel; and

infusing a solution of the initiator to the intended site of formation of the hydrogel.

7. The method of claim 6, wherein the initiator solution is infused via a separate access point from the gellable composition.

8. The method of claim 6, wherein the initiator solution is infused via a coaxial or side by side multi-lumen catheter, wherein the lumen infusing the initiator solution is shorter than the lumen delivering the gellable composition.

14. The method of claim 6, wherein the gellable composition comprises macromers having crosslinkable groups that are crosslinkable via free radical polymerization.

15. The method of claim 14, wherein the crosslinkable groups are olefinically unsaturated groups.

16. The method of claim 14, wherein the free radical polymerization is redox initiated.

17. The method of claim 16, wherein the redox initiation is performed via an oxidant and a reductant and one of the oxidant or reductant is the initiator.

9. A method of initiating formation of a hydrogel comprising the steps:

delivering a gellable composition that can form a hydrogel in response to an initiator to the intended site of formation of the hydrogel via a catheter; and

providing an initiator within the catheter so that when the gellable composition passes by the initiator, formation of the hydrogel is initiated.