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Polymorphism detection

  • US 20030134291A1
  • Filed: 03/28/2002
  • Published: 07/17/2003
  • Est. Priority Date: 06/25/1993
  • Status: Abandoned Application
First Claim
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1. An array of oligonucleotide probes for detecting a previously identified polymorphism in a target nucleic acid sequence, said array comprising at least one detection block of probes selected for detection of the previously identified polymorphism said detection block including first and second groups of probes that are complementary to said target nucleic acid sequence having first and second variants of said polymorphism, respectively, and further comprising third and fourth groups of probes, said third and fourth groups of probes having a sequence identical to said first and second groups of probes, respectively, except that said third and fourth groups of probes include all possible monosubstitutions of positions in said sequence that are within n bases of a base in said sequence that is complementary to said polymorphism, wherein n is from 1 to 5.

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