Design and signal recovery of biomolecular sensor arrays
First Claim
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1. An apparatus for detecting molecular presence, comprising:
- a substrate adapted to support an arrangement of sensor cells for detecting molecular presence;
a plurality of first sensor cells supported on said substrate;
each of said first sensor cells having an output adapted to output a recognition signal responsive to detection of molecular presence by the associated first sensor cell; and
a plurality of second sensor cells supported on said substrate, each said recognition signal including noise which can be approximated based on a position of one of said second sensor cells relative to the associated first sensor cell on said substrate, said first sensor cells and said second sensor cells arranged on said substrate such that at least one of said second sensor cells occupies said position relative to each of said first sensor cells.
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Abstract
The present invention provides an apparatus and method of reducing noise associated with biomolecular measurement systems. Sensor detection system noise characteristics in the presence of other sensor detection systems are determined and advantageously used to determine an arrangement of the individual sensor cells. The sensor cells are arranged on a substrate such that the system noise is determinable and can thus be filtered from the measurement signal.
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Citations
24 Claims
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1. An apparatus for detecting molecular presence, comprising:
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a substrate adapted to support an arrangement of sensor cells for detecting molecular presence;
a plurality of first sensor cells supported on said substrate;
each of said first sensor cells having an output adapted to output a recognition signal responsive to detection of molecular presence by the associated first sensor cell; and
a plurality of second sensor cells supported on said substrate, each said recognition signal including noise which can be approximated based on a position of one of said second sensor cells relative to the associated first sensor cell on said substrate, said first sensor cells and said second sensor cells arranged on said substrate such that at least one of said second sensor cells occupies said position relative to each of said first sensor cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of arranging on a substrate a plurality of first sensor cells and a plurality of second sensor cells for detection of molecular presence, comprising:
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determining that noise associated with an indication of molecular presence by any of said first sensor cells can be approximated based on a position of one of said second sensor cells relative to the first sensor cell on said substrate; and
arranging said first sensor cells and said second sensor cells on said substrate such that at least one of said second sensor cells occupies said position relative to each of said first sensor cells. - View Dependent Claims (15, 16, 17, 18)
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19. A method of arranging on a substrate a plurality of first sensor cells, a plurality of second sensor cells and a plurality of third sensor cells for detection of molecular presence, comprising:
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determining that noise associated with an indication of molecular presence by any of said first sensor cells can be approximated based on a position of one of said second sensor cells relative to the first sensor cell on said substrate;
determining that further noise associated with an indication of molecular presence by any of said first sensor cells can be approximated based on a further position of one of said third sensor cells relative to the first sensor cell on said substrate; and
arranging said first sensor cells and said second sensor cells and said third sensor cells on said substrate such that at least one of said second sensor cells occupies said position relative to each of said first sensor cells and at least one of said third sensor cells occupies said further position relative to each of said first sensor cells. - View Dependent Claims (21, 22, 23, 24)
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Specification