Multi-modal optical tissue diagnostic system
First Claim
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1. A method for diagnosing a condition of a target tissue, comprising the steps of:
- a.) irradiating a target tissue with excitation electromagnetic radiation;
b.) sensing a returned electromagnetic radiation returned from the target tissue;
c.) determining characteristics of the returned electromagnetic radiation using at least two spectroscopic methods;
d.) combining the characteristics determined by the at least two spectroscopic methods, thereby decoupling and detecting biochemical changes and morphological changes in the target tissue; and
e.) determining a condition of the target tissue based on the combined determined characteristics.
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Abstract
An apparatus and method according to the invention combine more than one optical modality (spectroscopic method), including but not limited to fluorescence, absorption, reflectance, polarization anisotropy, and phase modulation, to decouple morphological and biochemical changes associated with tissue changes due to disease, and thus to provide an accurate diagnosis of the tissue condition.
146 Citations
82 Claims
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1. A method for diagnosing a condition of a target tissue, comprising the steps of:
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a.) irradiating a target tissue with excitation electromagnetic radiation;
b.) sensing a returned electromagnetic radiation returned from the target tissue;
c.) determining characteristics of the returned electromagnetic radiation using at least two spectroscopic methods;
d.) combining the characteristics determined by the at least two spectroscopic methods, thereby decoupling and detecting biochemical changes and morphological changes in the target tissue; and
e.) determining a condition of the target tissue based on the combined determined characteristics. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 64, 74, 75, 76, 77, 78, 79)
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19. A system for determining a condition of a target tissue in a human or animal, comprising:
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a electromagnetic radiation source for providing excitation electromagnetic radiation;
a device that couples the excitation electromagnetic radiation to a target tissue;
a device that senses electromagnetic radiation returned from the target tissue;
a processor configured to determine characteristics of the returned electromagnetic radiation using at least two spectroscopic methods, wherein the processor combines the characteristics determined by each of the at least two spectroscopic methods in order to decouple and detect biochemical changes and morphological changes in the target tissue and determines a condition of the target tissue based on the combined determined characteristics. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 58, 59, 60, 61, 62, 63, 65, 66, 67, 68, 69, 70, 71, 72, 73, 80)
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36. A method for diagnosing diseased tissue in a human or animal, comprising:
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irradiating a target tissue with excitation electromagnetic radiation;
sensing a returned electromagnetic radiation returned from the target tissue;
determining characteristics of the returned electromagnetic radiation using at least two spectroscopic methods, thereby decoupling and detecting biochemical changes and morphological changes in the target tissue occurring due to disease; and
determining a condition of the target tissue based the determined characteristics. - View Dependent Claims (81)
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37. A system for determining a condition of a target tissue in a human or animal, comprising:
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an electromagnetic radiation source for providing excitation electromagnetic radiation;
a device that couples the excitation electromagnetic radiation to a target tissue;
a device that senses electromagnetic radiation returned from the target tissue; and
a processor configured to determine characteristics of the returned electromagnetic radiation using at least two spectroscopic methods, thereby decoupling and detecting biochemical changes and morphological changes in the target tissue occurring due to disease and determine a condition of the target tissue based on the determined characteristics. - View Dependent Claims (82)
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Specification