Implantable osmotic pump
First Claim
1. An implantable osmotic pump for delivering a pharmaceutical agent to a patient, comprising:
- an osmotic engine;
a substantially toroidal compartment adapted to store a pharmaceutical agent, and a piston disposed within the compartment, the osmotic engine being configured to cause the piston to travel within the compartment and deliver the pharmaceutical agent when the pump is implanted in the patient.
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Accused Products
Abstract
An implantable osmotic pump for delivering a pharmaceutical agent to a patient includes an osmotic engine, a substantially toroidal compartment disposed at least partially around the osmotic engine and a piston disposed within the compartment. The osmotic engine is configured to cause the piston to travel within the compartment and deliver a dose pharmaceutical agent contained within the compartment when the pump is implanted in an aqueous environment. A dose escalation assembly may be fitted to the pump, the dose escalation assembly being adapted to selectively increase the rate at which the pharmaceutical agent is delivered from the pump.
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Citations
103 Claims
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1. An implantable osmotic pump for delivering a pharmaceutical agent to a patient, comprising:
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an osmotic engine;
a substantially toroidal compartment adapted to store a pharmaceutical agent, and a piston disposed within the compartment, the osmotic engine being configured to cause the piston to travel within the compartment and deliver the pharmaceutical agent when the pump is implanted in the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A kit, comprising:
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an implantable osmotic pump for delivering a pharmaceutical agent to a patient, including an osmotic engine, a tube coiled around the osmotic engine, the tube defining an inner tube-shaped compartment adapted to store a pharmaceutical agent, and a piston disposed within the tube-shaped compartment, the osmotic engine being configured to exert a force on the piston to cause the piston to travel within the tube-shaped compartment and deliver the pharmaceutical agent when the pump is implanted in the patient, and a catheter configured to attach to the pump. - View Dependent Claims (59, 60, 61, 62, 63, 64, 66)
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65. The kit of claim 65, wherein the dose escalation pen includes a dose selection actuator that is adapted to re-configure the dose escalation pen to selectively breach one of the first and second impermeable membranes.
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67. A method of delivering a pharmaceutical agent to a patient, comprising steps of:
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implanting a pump into the patient, the pump including a pump engine and a compartment adapted to store a pharmaceutical agent, the compartment defining at least a partial torus around the osmotic engine, and causing a piston to travel a distance within the compartment and to deliver a dose of pharmaceutical agent out of the compartment, the dose corresponding to the distance traveled by the piston within the compartment. - View Dependent Claims (68, 69, 70, 71, 72, 73)
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74. A pump, comprising:
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a pump engine;
a tube coiled around the engine, the tube defining an inner tube-shaped compartment adapted to store a fluid, and a piston disposed within the tube-shaped compartment, the engine being adapted to cause the piston to travel within the tube-shaped compartment and to force a dose of the fluid out of the pump. - View Dependent Claims (75, 76, 77, 78, 79, 80, 81)
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82. An osmotic pump, comprising:
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an osmotic engine, and a pump housing enclosing the osmotic engine and defining a substantially toroidal space adapted to contain a volume of pharmaceutical agent. - View Dependent Claims (83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94)
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95. An implantable osmotic pump, comprising:
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a semipermeable membrane;
a housing adapted to enclose a volume of pharmaceutical agent and a portion of the semipermeable membrane;
an osmotic engine adapted to cause the pharmaceutical agent to be delivered out of he pump as an osmotic pressure differential develops across the semipermeable membrane, and at least one of;
an OFF switch, the OFF switch being effective to reduce the osmotic pressure differential across the semipermeable membrane substantially to zero, and an ON switch, the ON switch being effective to enable the pump to begin to deliver the pharmaceutical agent out of the pump. - View Dependent Claims (96, 97, 98, 99)
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- 100. A filter assembly for an osmotic pump, the filter assembly defining a first end configured to mate with the osmotic pump a second end configured to be exposed, in use, to an aqueous environment and including a filter between the first and second ends.
Specification