Amperometric sensors using synthetic substrates based on modeled active-site chemistry
First Claim
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1. A device for detecting an analyte in an aqueous solution, said device comprising:
- (a) a carrier;
(b) a dot electrode disposed on said carrier; and
(c) one or more sensing elements disposed upon said dot electrode and reactive to said analytes.
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Abstract
A biosensor for detecting and measuring analytes in an aqueous solution. The biosensor device has a sensor design based on modeling of the active-site chemistry of reactive molecules such as enzymes, antibodies and cellular receptors. The sensor design takes advantage of a synthetic polymer modeled after these reactive molecules to provide reversible, sensitive and reliable detection of analytes in the form of a versatile and economical device.
33 Citations
74 Claims
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1. A device for detecting an analyte in an aqueous solution, said device comprising:
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(a) a carrier;
(b) a dot electrode disposed on said carrier; and
(c) one or more sensing elements disposed upon said dot electrode and reactive to said analytes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A device for detecting an analyte in an aqueous solution;
- said device comprising;
(a) a carrier;
(b) a dot electrode disposed on said carrier;
(c) one or more sensing elements disposed upon said dot electrode and reactive to such analyte;
whereinsaid sensing elements comprise a synthetic unit modeled after an active-site chemistry of a reac tive molecule; and
(d) a signal transduction element. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
- said device comprising;
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60. A method for making a device that comprises sensing elements reactive to one or more analytes in an aqueous solution, said method comprising the steps of:
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coating a noble metal substrate with a synthetic polymer;
wherein the synthetic polymer is modeled after an active-site chemistry of a molecule reactive to the analyte; and
disposing the substrate upon a carrier. - View Dependent Claims (61, 62, 63, 64, 65, 66)
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67. A method for using a device for detecting one or more analytes in an aqueous solution, wherein said device comprises (1) a carrier, (2) a dot electrode disposed on said carrier, (3) one or more sensing elements disposed upon said dot electrode and reactive to said analytes, wherein said sensing elements comprise an active-site of a reactive biochemical molecule, and (4) a signal transduction element;
- said method comprising the steps of;
(a) causing said one or more sensing elements to be exposed to said aqueous solution; and
(b) monitoring response of said one or more sensing elements. - View Dependent Claims (68, 69, 70, 71, 72, 73, 74)
- said method comprising the steps of;
Specification