Device for irradiating a tumor tissue

• US 20030136924A1
• Filed: 01/08/2003
• Published: 07/24/2003
• Est. Priority Date: 06/30/2000
• Status: Active Grant

• Current Assignee: Gessellschaft Fur Schwerionenforschung MbH
• Original Assignee: Gessellschaft Fur Schwerionenforschung MbH
• Inventors: Kraft, Gerhard, Weber, Ulrich
• Granted Patent: US 6,710,362 B2
• Time in Patent Office: Days
• US Class Current: 250/492.3
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 5/1043 Scanning the radiation beam, e.g. spot scanning or raster scanning
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment

Abstract

The invention relates to an apparatus and a method for irradiating tumour tissue (3) of a patient (10) by means of an ion beam (2). For that purpose, the apparatus has a deflecting device (1) for the ion beam (2) for slice-wise and area-wise scanning of the tumour tissue (3) and an ion beam energy control device for slice-wise and depth-wise scanning of the ion beam (2). An electromechanically driven ion-braking device (11, 12) is provided as a depth-wise scanning adaptation apparatus (5) for adapting the range of the ion beam (2) and has faster depth-wise adaptation than the energy control device of an accelerator. The movement of a patient is monitored by means of a movement detection device (7) for detecting a temporal and positional change in the location of the tumour tissue (3) in a treatment space (8). A control device controls the deflecting device (1) and the depth-wise adaptation apparatus (5) for adjusting the ion beam direction and ion beam range, respectively, when scanning the tumour tissue (3) in the course of temporal and positional change in the location of the tumour tissue (3) in the treatment space (8).

Claims

1. Apparatus for irradiating tumour tissue (3) of a patient (10) by means of an ion beam (2), having

a deflecting device (1) for the ion beam (2) for slice-wise and area-wise scanning of the tumour tissue (3) and

an accelerator having an ion beam energy control device for step-wise and depth-wise scanning of the tumour tissue (3),

characterised in that

the apparatus further has:

an electromechanically driven ion-braking device (11, 12), which is used as a depth-wise scanning adaptation apparatus (5) for adapting the range of the ion beam (2) and which has faster depth-wise adaptation than the energy control device of the accelerator,

a movement detection device (7) for detecting a temporal and positional change in the location of the tumour tissue (3) in a treatment space (8), and

a control device which controls the deflecting device (1) and the depth-wise scanning adaptation apparatus (5) for adjusting the ion beam direction and the ion beam range, respectively, when scanning the tumour tissue (3) in the course of temporal and positional change in the location of the tumour tissue (3) in the treatment space (8).

2. Apparatus according to claim 1, characterised in that the deflecting device (1) has two electromagnets (13, 14), which, for slice-wise and area-wise scanning of the tumour tissue (3), deflect an ion beam orthogonally to the ion beam axis (15) in an X direction and a Y direction, which are in turn located perpendicular to one another.

3. Apparatus according to claim 2, characterised in that the electromagnets are controlled by fast-reacting power units.

4. Apparatus according to one of the preceding claims, characterised in that the apparatus has accelerators by means of which the energy of the ion beam (2) is arranged to be so adjusted that the tumour tissue (3) can be irradiated slice-wise, staggered in terms of depth.

5. Apparatus according to one of the preceding claims, characterised in that the depth-wise scanning adaptation apparatus (5) has, for fast depth-wise scanning adaptation in the case of moving tumour tissue (3), an electromechanically operated ion-braking device which has two ion-braking plates (16, 17), which in cross-section are wedge-shaped and which cover the entire irradiation field of the ion beam (2).

6. Apparatus according to claim 5, characterised in that the ion-braking plates (16, 17) are mounted on linear motors.

7. Apparatus according to claim 5, characterised in that the ion-braking plates (16, 17) are arranged on electromagnetically actuatable carriages.

8. Apparatus according to one of claims 5 to 7, characterised in that the ion-braking plates are arranged to be displaced in opposite directions, their wedge-shaped cross-sections overlapping in the region of the ion beam (2).

9. Apparatus according to one of claims 1 to 4, characterised in that the depth-wise scanning adaptation apparatus (5) has, for fast depth-wise scanning adaptation in the case of moving tumour tissue (3), a hydraulically assisted ion-braking device wherein the thickness of a water layer (30) between two transparent plates (31, 32), through which the ion beam (2) is directed, is adapted to the movements of the tumour tissue.

10. Apparatus according to claim 9, characterised in that the two transparent plates (31, 32) are arranged to be moved towards one another and have water in their intermediate space (33).

11. Apparatus according to claim 9 or 10, characterised in that the spacing between the transparent plates (31, 32) and, consequently, the thickness of the water layer (33) are arranged to be adjusted by means of linear motors (34, 35).

12. Apparatus according to one of claims 9 to 11, characterised in that the depth-wise scanning adaptation apparatus (5) has a hydraulically operated compensation tank (36) for the water volume between the transparent plates (31, 32).

13. Apparatus according to one of claims 9 to 12, characterised in that a bellows (37) is arranged between the transparent plates (31, 32).

14. Apparatus according to one of the preceding claims, characterised in that the movement detection device (7) has at least two measurement sensors (19, 20), which detect, from two spatial angles (α

, β

) in relation to an ion beam axis (15), the temporal and positional location of markings on a region of the body of a patient (10) that contains tumour tissue(3).

15. Apparatus according to claim 14, characterised in that the measurement sensors (19, 20) are precision video cameras (21, 22), which cooperate with an image-evaluating unit.

16. Apparatus according to one of claims 1 to 13, characterised in that the movement detection device (7) has at least two measurement sensors (19, 20), which are arranged orthogonally to ion beam and perpendicular to one another, the temporal and positional change in the location of the tumour tissue being monitored by short pulses of X-ray beams (38, 39), and the movement detection device (7) having, for detection of the images of the tumour tissue, correspondingly arranged sensor plates (40, 41) and an evaluating unit (42).

17. Apparatus according to one of the preceding claims, characterised in that an ionisation chamber having a fast read-out for monitoring the intensity of the ion beam flow is arranged as a transmission counter in the beam path of the ion beam (2).

18. Apparatus according to claim 17, characterised in that the ionisation chamber is arranged between the deflecting device (1) and the depth-wise scanning adaptation apparatus (5).

19. Method of irradiating tumour tissue of a patient by means of an ion beam (2), which method comprises the following method steps:

placing the patient (10) on an apparatus matched to the contour of the patient for positioning the patient (10) in an irradiation space (8),

applying markings to a region of the body of the patient (10), close to the tumour tissue (3),

determining the temporal and positional change in the markings by means of a movement detection device (7) or capturing X-ray images of the tumour tissue from two mutually perpendicular directions of X-ray beams orthogonal to the ion beam,

adjusting the ion beam (2), whilst scanning the tumour tissue using an ion beam deflecting device (1) and an ion beam energy control device, by means of an additional depth-wise scanning adaptation apparatus (5), which adapts the range of the ion beam to the temporal and positional changes in the markings or tumour tissue, determined by the movement detection device (7), in co-operation with the ion beam deflecting device (1).