Closed substrate platforms suitable for analysis of biomolecules
First Claim
1. A closed substrate platform comprising:
- a container comprising an area for sample analysis and a microfluidic analysis platform, the container comprising (i) at least one inlet for the introduction of fluid to the sample analysis area and (ii) an outlet for removal of fluid from the sample analysis area;
a vent for expulsion of air from the container.
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Abstract
The invention relates to novel analysis slides or substrates with a closed configuration. The slides may be used for any application which normally utilizes a conventional microscope slide and can be used in conjunction with any type of equipment typically used to manipulate or evaluate a standard microscope slide. In particular, the invention provides closed slides for covalent immobilization of polypeptides and nucleic acids. Further provided are methods for carrying out biological assays using arrays of biomolecules immobilized on the slides of the invention. The arrays of the invention are comprised of a unique meandering or straight channel design as compared to the rectangular design of conventional arrays.
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Citations
50 Claims
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1. A closed substrate platform comprising:
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a container comprising an area for sample analysis and a microfluidic analysis platform, the container comprising (i) at least one inlet for the introduction of fluid to the sample analysis area and (ii) an outlet for removal of fluid from the sample analysis area;
a vent for expulsion of air from the container. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 41, 42, 43, 44, 45, 46)
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28. A closed substrate platform for analysis of biomolecules comprising:
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a container comprising an area for sample analysis and a microfluidic analysis system comprising a non-linear flow path, the container comprising (i) at least one inlet for the introduction of fluid to the sample analysis area and (ii) an outlet for removal of fluid from the sample analysis area;
a vent for expulsion of air from the container, the sample analysis area comprising one or more biomolecules. - View Dependent Claims (29, 30, 31, 32, 33)
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34. A closed substrate platform comprising:
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a container comprising an area for sample analysis and a microfluidic analysis platform, the container comprising (i) at least one inlet for the introduction of fluid to the sample analysis area and (ii) an outlet for removal of fluid from the sample analysis area, the container comprising at least two parts adhered to each other, wherein the two parts define the microfluidic analysis platform;
a vent for expulsion of air from the container. - View Dependent Claims (35, 36, 37, 38, 39, 40)
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47. A method for providing a closed substrate platform suitable for analysis of biomolecules, comprising:
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providing an analysis platform part having a defined channel system depressed in a planar surface thereof, to provide an analysis sample flow path; and
applying a planar substrate over the channel system to provide a closed sample flow path. - View Dependent Claims (48, 49, 50)
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Specification