Colorimetric artificial nose having an array of dyes and method for artificial olfaction

• US 20030143112A1
• Filed: 10/24/2002
• Published: 07/31/2003
• Est. Priority Date: 03/21/2000
• Status: Active Grant

• Current Assignee: 352 HENRY ADMINISTRATION BLDG.
• Original Assignee: Board of Trustees of The University of Illinois
• Inventors: Rakow, Neal A., Sen, Avijit, Suslick, Kenneth S., McNamara, William B. III, Kosal, Margaret E.
• Granted Patent: US 7,261,857 B2
• Time in Patent Office: Days
• US Class Current: 422/55
• CPC Class Codes: G01N 21/272 for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
• CPC Class Codes: G01N 21/78 producing a change of colour
• CPC Class Codes: G01N 31/22 using chemical indicators G01N31/02 takes precedence

Abstract

The present invention involves an artificial nose having an array comprising at least a first dye and a second dye in combination and having a distinct spectral response to an analyte. In one embodiment, the first and second dyes are from the group comprising chemoresponsive dyes, and the second dye is distinct from the first dye. In one embodiment, the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phthalocyanine, and salen, or their metal complexes. In another embodiment, the second dye is selected from the group of dyes consisting of acid-base indicator dyes and solvatochromic dyes. The present invention is particularly useful in detecting metal ligating vapors. Further, the array of the present invention can be connected to a visual display device.

Claims

1. An artificial nose comprising an array, the array comprising at least a first dye and a second dye deposited directly onto a single support in a predetermined pattern combination, the combination of the dyes in the array having a distinct and direct spectral absorbance or reflectance response to distinct analytes, wherein the first dye and the second are selected from the group of dyes consisting of chemoresponsive dyes, and the second dye is distinct from the first dye.

2. The artificial nose of claim 1 wherein the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phtahlocyanine, and salen and their metal complexes.

3. The artificial nose of claim 1 wherein the second dye is selected from the group consisting of acid-base indicator dyes and solvatochromic dyes.

4. The artificial nose of claim 1 wherein the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phtahlocyanine, and salen and their metal complexes, and the second dye is distinct from the first dye and selected from the group of dyes consisting of acid-base indicator dyes and solvatochromic dyes.

5. The artificial nose of claim 1 wherein the first dye is a metalloporphyrin.

6. The artificial nose of claim 1 wherein the second dye is an acid-base indicator dye.

7. The artificial nose of claim 1 wherein the second dye is a solvatochromic dye.

8. The artificial nose of claim 1 wherein the second dye is selected from the group consisting of Chlorphenol Red, Bromocresol Green, Bromocresol Purple, Bromothymol Blue, Phenol Red, Thymol Blue, Cresol Red, Alizarin, Mordant Orange, Methyl Orange, Methyl Red, Reichardt'"'"'s Dye, Nile Red, Congo Red, Victoria Blue B, Eosin Blue, Fat Brown B, Benzopurpurin 4B, Phloxine B, Orange G, Metanil Yellow, Naphthol Green B, Methylene Blue, Safranine O, Methylene Violet 3RAX, Sudan Orange G, Morin Hydrate, Neutral Red, Disperse Orange 25, Rosolic Acid, Fat Brown RR, Cyanidin chloride, 3,6-Acridineamine, 6′

-Butoxy-2,6-diamino-3,3′

-azodipyridine, para-Rosaniline Base, Acridine Orange Base, Crystal Violet, and Malachite Green Carbinol Base.

9. The artificial nose of claim 2 wherein the second dye is selected from the group consisting of Chlorphenol Red, Bromocresol Green, Bromocresol Purple, Bromothymol Blue, Phenol Red, Thymol Blue, Cresol Red, Alizarin, Mordant Orange, Methyl Orange, Methyl Red, Reichardt'"'"'s Dye, Nile Red, Congo Red, Victoria Blue B, Eosin Blue, Fat Brown B, Benzopurpurin 4B, Phloxine B, Orange G, Metanil Yellow, Naphthol Green B, Methylene Blue, Safranine O, Methylene Violet 3RAX, Sudan Orange G, Morin Hydrate, Neutral Red, Disperse Orange 25, Rosolic Acid, Fat Brown RR, Cyanidin chloride, 3,6-Acridineamine, 6′

-Butoxy-2,6-diamino-3,3′

-azodipyridine, para-Rosaniline Base, Acridine Orange Base, Crystal Violet, and Malachite Green Carbinol Base.

10. The artificial nose of claim 1 wherein the first dye is a porphyrin and has a periphery and a superstructure bonded to the periphery.

31. The artificial nose of claim 1 further comprising a low volatility liquid.

32. The artificial nose of claim 2 further comprising a low volatility liquid.

38. A table of responses of the array of the artificial nose of claim 1 to a plurality of distinct analytes.

11. A method of detecting an analyte comprising the steps of:

forming an array of at least a first dye and a second dye deposited directly onto a single support in a predetermined pattern combination, the combination of the dyes in the array having a distinct and direct spectral absorbance or reflectance response to distinct analytes wherein the first dye and the second dye are selected from the group consisting of chemoresponsive dyes, and the second dye is distinct from the first dye,

subjecting the array to an analyte,

inspecting the array for a distinct and direct spectral absorbance or reflectance response,

and correlating the distinct and direct spectral response to the presence of the analyte.

12. The method of claim 11 wherein the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phtahlocyanine, and salen and their metal complexes.

13. The method of claim 11 wherein the second dye is selected from the group consisting of acid-base indicator dyes and solvatochromic dyes.

14. The method of claim 11 wherein the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phtahlocyanine, and salen and their metal complexes, and the second dye is distinct from the first dye and selected from the group of acid-base indicator dyes and solvatochromic dyes.

15. The method of claim 11 wherein the first dye is a metalloporphyrin.

16. The method of claim 11 wherein the second dye is an acid-base indicator dye.

17. The method of claim 11 wherein the second dye is a solvatochromic dye.

18. The method of claim 11 wherein the second dye is selected from the group consisting of Chlorphenol Red, Bromocresol Green, Bromocresol Purple, Bromothymol Blue, Phenol Red, Thymol Blue, Cresol Red, Alizarin, Mordant Orange, Methyl Orange, Methyl Red, Reichardt'"'"'s Dye, Nile Red, Congo Red, Victoria Blue B, Eosin Blue, Fat Brown B, Benzopurpurin 4B, Phloxine B, Orange G, Metanil Yellow, Naphthol Green B, Methylene Blue, Safranine O, Methylene Violet 3RAX, Sudan Orange G, Morin Hydrate, Neutral Red, Disperse Orange 25, Rosolic Acid, Fat Brown RR, Cyanidin chloride, 3,6-Acridineamine, 6′

-Butoxy-2,6-diamino-3,3′

-azodipyridine, para-Rosaniline Base, Acridine Orange Base, Crystal Violet, and Malachite Green Carbinol Base.

19. The method of claim 12 wherein the second dye is selected from the group consisting of Chlorphenol Red, Bromocresol Green, Bromocresol Purple, Bromothymol Blue, Phenol Red, Thymol Blue, Cresol Red, Alizarin, Mordant Orange, Methyl Orange, Methyl Red, Reichardt'"'"'s Dye, Nile Red, Congo Red, Victoria Blue B, Eosin Blue, Fat Brown B, Benzopurpurin 4B, Phloxine B, Orange G, Metanil Yellow, Naphthol Green B, Methylene Blue, Safranine O, Methylene Violet 3RAX, Sudan Orange G, Morin Hydrate, Neutral Red, Disperse Orange 25, Rosolic Acid, Fat Brown RR, Cyanidin chloride, 3,6-Acridineamine, 6′

-Butoxy-2,6-diamino-3,3′

-azodipyridine, para-Rosaniline Base, Acridine Orange Base, Crystal Violet, and Malachite Green Carbinol Base.

20. The method of claim 11 wherein the first dye is a porphyrin and has a periphery and a superstructure bonded to the periphery.

33. The method of claim 11, further comprising the step of adding a low volatility liquid to the array.

34. The method of claim 12, further comprising the step of adding a low volatility liquid to the array.

37. The method of claim 11 further comprising the step of forming a table of responses of the array to a plurality of distinct analytes.

21. An artificial tongue comprising an array, the array comprising at least a first dye and a second dye deposited directly onto a single support in a predetermined pattern combination, the combination of the dyes in the array having a distinct and direct spectral absorbance or reflectance response to distinct analytes in solution or liquid analytes, or analytes in a solid or solid analytes, wherein the first dye and the second dye are selected from the group consisting of chemoresponsive dyes, and the second dye is distinct from the first dye.

22. The artificial tongue of claim 21 wherein the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phtahlocyanine, and salen and their metal complexes.

23. The artificial tongue of claim 21 wherein the second dye is selected from the group consisting of acid-base indicator dyes and solvatochromic dyes.

24. The artificial tongue of claim 21 wherein the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phtahlocyanine, and salen and their metal complexes, and the second dye is distinct from the first dye and selected from the group of dyes consisting of acid-base indicator dyes and solvatochromic dyes.

25. The artificial tongue of claim 21 wherein the first dye is a metalloporphyrin.

26. The artificial tongue of claim 21 wherein the second dye is an acid-base indicator dye.

27. The artificial tongue of claim 21 wherein the second dye is a solvatochromic dye.

28. The artificial tongue of claim 21 wherein the second dye is selected from the group consisting of Chlorphenol Red, Bromocresol Green, Bromocresol Purple, Bromothymol Blue, Phenol Red, Thymol Blue, Cresol Red, Alizarin, Mordant Orange, Methyl Orange, Methyl Red, Reichardt'"'"'s Dye, Nile Red, Congo Red, Victoria Blue B, Eosin Blue, Fat Brown B, Benzopurpurin 4B, Phloxine B, Orange G, Metanil Yellow, Naphthol Green B, Methylene Blue, Safranine O, Methylene Violet 3RAX, Sudan Orange G, Morin Hydrate, Neutral Red, Disperse Orange 25, Rosolic Acid, Fat Brown RR, Cyanidin chloride, 3,6-Acridineamine, 6′

-Butoxy-2,6-diamino-3,3′

-azodipyridine, para-Rosaniline Base, Acridine Orange Base, Crystal Violet, and Malachite Green Carbinol Base.

29. The artificial tongue of claim 22 wherein the second dye is selected from the group consisting of Chlorphenol Red, Bromocresol Green, Bromocresol Purple, Bromothymol Blue, Phenol Red, Thymol Blue, Cresol Red, Alizarin, Mordant Orange, Methyl Orange, Methyl Red, Reichardt'"'"'s Dye, Nile Red, Congo Red, Victoria Blue B, Eosin Blue, Fat Brown B, Benzopurpurin 4B, Phloxine B, Orange G, Metanil Yellow, Naphthol Green B, Methylene Blue, Safranine O, Methylene Violet 3RAX, Sudan Orange G, Morin Hydrate, Neutral Red, Disperse Orange 25, Rosolic Acid, Fat Brown RR, Cyanidin chloride, 3,6-Acridineamine, 6′

-Butoxy-2,6-diamino-3,3′

-azodipyridine, para-Rosaniline Base, Acridine Orange Base, Crystal Violet, and Malachite Green Carbinol Base.

30. The artificial tongue of claim 21 wherein the first dye is a porphyrin and has a periphery and a superstructure bonded to the periphery.

35. The artificial tongue of claim 21 further comprising a low volatility liquid.

36. The artificial tongue of claim 22 further comprising a low volatility liquid.

39. A table of responses of the artificial tongue of claim 21 to a plurality of distinct analytes.