Chemokine beta-1 fusion proteins
First Claim
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1. A Ckb1 protein comprising a deletion in amino acid residues selected from:
- (a) the amino terminus, (b) the carboxy terminus, and (c) the amino terminus and carboxy terminus of the polypeptide shown in FIG. 1 (SEQ ID NO;
2).
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Abstract
The present invention relates to novel chemokine polypeptides and encoding nucleic acids. More specifically, therapeutic compositions and methods are provided using isolated nucleic acid molecules encoding a human chemokine beta-1 (Ckβ-1 or Ckb1) polypeptide (previously termed monocyte-colony inhibitory factor (M-CIF), MIP1-γ, and Hemofiltrate CC chemokine-1 (HCC-1)), and Ckb1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. Also provided are methods of treating, preventing, ameliorating diseases using such compounds.
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Citations
17 Claims
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1. A Ckb1 protein comprising a deletion in amino acid residues selected from:
- (a) the amino terminus, (b) the carboxy terminus, and (c) the amino terminus and carboxy terminus of the polypeptide shown in FIG. 1 (SEQ ID NO;
2). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- (a) the amino terminus, (b) the carboxy terminus, and (c) the amino terminus and carboxy terminus of the polypeptide shown in FIG. 1 (SEQ ID NO;
Specification