Method of treating pain

• US 20030143249A1
• Filed: 01/31/2002
• Published: 07/31/2003
• Est. Priority Date: 01/30/2002
• Status: Active Grant

• Current Assignee: 1474791 Ontario Limited
• Original Assignee: 1474791 Ontario Limited
• Inventors: Lamb, Gregory Blair
• Granted Patent: US 6,806,251 B2
• Time in Patent Office: Days
• US Class Current: 424/239.1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 38/4893 Botulinum neurotoxin (3.4.24.69)
• CPC Class Codes: A61P 23/00 Anaesthetics
• CPC Class Codes: A61P 23/02 Local anaesthetics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: Y10S 128/907 Acupuncture

Abstract

The invention provides a method for treatment of pain, the method comprising administering to the intrinsic spinal muscles of a mammal an amount of an agent sufficient to paralyze said muscles.

Claims

1. A method for the treatment of pain, said method comprising administering to the intrinsic spinal muscles of a mammal an amount of an agent sufficient to paralyze said muscles.

2. A method according to claim 1, wherein said agent is botulinum toxin.

3. A method according to claim 2, wherein said toxin is botulinum toxin type A.

4. A method according to any one of claims 2 or 3, wherein said toxin is administered in an amount between 1 and 30 mouse units per injection site.

5. A method according to claim 4, wherein said toxin is administered in a single injection.

6. A method according to claim 4, wherein said toxin is administered via a plurality of injections.

7. The method of any one of claims 1 to 6, further comprising the administration of a tissue growth factor to enhance healing.

8. The use of botulinum toxin as an agent for the injection of an intrinsic spinal muscle.

9. The use of a paralysing agent in combination with a growth factor to treat spinal compression.

10. A kit for the treatment of pain by injection of the intrinsic spinal muscles, said kit comprising:

a) a paralyzing agent;

b) an injection syringe with needle; and

c) an acupuncture needle with injector system.

16. A kit according to claim 10 or claim 11, further comprising a tissue growth factor.

17. A kit according to claim 16, wherein the injection needle is a 2½

″

-50-60 mm spinal injection needle having a 20-25 gauge.

18. A kit according to claim 17, wherein the acupunture needle is a 2½

″

-50-60 mm acupuncture 0.25 mm to 0.50 mm gauge needle with injector system.

11. An intrinsic muscle injection kit comprising:

a) botulinum toxin;

b) saline for diluting said toxin;

c) a syringe with needle for dispensing said saline into the toxin;

d) a spinal botulinum injection needle;

e) an acupuncture needle with spinal acupuncture injector system; and

f) at least one injection syringe.

12. A kit according to claim 11, wherein said botulinum toxin is provided in a vial containing 25, 50, 75 or 100 units.

13. A kit according to claim 12, wherein said botulinum toxin comprises at least one of chains A to G or fragments thereof.

14. A kit according to claim 13, wherein said toxin is botulinum toxin A.

15. A kit according to claim 14, further comprising a local anesthetic selected from the group consisting of Naropin, Xylocaine and Marcaine.

19. A kit according to claim 11, wherein the at least one injection syringe is a 1-4 cc/ml syringe with markings delineating dose line separations.

20. A kit according to claim 11, further comprising an instructional video for physicians demonstrating injection of intrinsic muscles in the cervical, thoracic or lumber areas.