Medical uses of in situ formed gels
First Claim
1. A drug delivery composition capable of gelling in situ containing approximately 0.01% to about 60% by weight of medicament or pharmaceutical, approximately 1-50% of water soluble film forming polymer and an ionic polysaccharide capable of cross-linking.
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Accused Products
Abstract
Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
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Citations
20 Claims
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1. A drug delivery composition capable of gelling in situ containing approximately 0.01% to about 60% by weight of medicament or pharmaceutical, approximately 1-50% of water soluble film forming polymer and an ionic polysaccharide capable of cross-linking.
- 2. The drug delivery composition of claim 2 wherein the drug delivery composition is an aqueous composition.
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8. The drug delivery composition of claim 8 wherein the alginate gums are alkali metal alginates and the metal is selected from the group consisting of sodium, potassium, lithium, rubidium and cesium salts.
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11. A drug delivery composition capable of gelling in situ upon release of a counter ion containing approximately 0.01% to about 60% by weight of medicament or pharmaceutical, approximately 1-50% of water soluble film forming polymer and an ionic polysaccharide capable of cross-linking.
- 12. The drug delivery composition of claim 12 wherein the counter ion is provided in latent form by microencapsulation of the counter ion in a heat sensitive medium which releases the counter ion at body temperature and causes the drug delivery composition to gel.
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17. A drug delivery composition which gels in situ which may be delivered topically to body cavities or by injection comprising approximately 0.01% to about 60% by weight of medicament or pharmaceutical, approximately 1-50% of water soluble film forming polymer, and an ionic polysaccharide which cross-links only after the drug delivery composition is administered in situ.
- 18. The drug delivery composition of claim 18 wherein the medicament of pharmaceutical is selected from the group consisting of antibacterials, antihistamines, decongestants, antiunflammatories, antiparisitics, miotics, anticholinergies, antivirals, local anesthetics, antifungals, immunosuppressants, amoebicidals, trichomonocidals, analgesics, mydriatics, antiglaucoma drugs, carbonic anyhydrase inhibitors, opthalmic diagnostic agents, opthalimic agents used as adjuvents in surgery, chelating agents, antineoplastics, antihypertensives, muscle relaxants and diagnostics.
Specification