Self-calibrating body anayte monitoring system
First Claim
1. A body analyte monitoring device comprising a) a microdialysis needle with an inlet port and an outlet port b) a reservoir containing a perfusate in fluid communication with said inlet port of said microdialysis needle c) the outlet port of said microdialysis needle in fluid communication with an analysis compartment wherein said body analyte acquired by said microdialysis needle may be assayed c) pumping means to move said perfusate from said reservoir into said inlet port of said microdialysis needle, through said microdialysis needle, out of said outlet port of said microdialysis needle, and into said analysis compartment d) a reservoir containing a body analyte calibration fluid in fluid communication with said analysis compartment e) pumping means to move said calibration fluid from said calibration fluid containing reservoir into said analysis compartment f) a reservoir containing a reagent solution in fluid communication with said analysis compartment g) pumping means to move said reagent solution from said reagent solution reservoir into said analysis compartment h) fluid sequencing means whereby the fluid moving into said analysis compartment may be selected as either said perfusate from said outlet port of said microdialysis needle mixed with said reagent solution or said calibration fluid mixed with said reagent solution.
0 Assignments
0 Petitions
Accused Products
Abstract
A wearable periodic self-calibrating body analyte monitoring system based on the principles of microdialysis for measurement of a body analyte is disclosed. In a preferred embodiment, the system is designed to measure glucose, and can be held on the body with a skin adhesive for comfort. The system may be combined with an insulin delivery system to create an artificial pancreas.
-
Citations
31 Claims
-
1. A body analyte monitoring device comprising
a) a microdialysis needle with an inlet port and an outlet port b) a reservoir containing a perfusate in fluid communication with said inlet port of said microdialysis needle c) the outlet port of said microdialysis needle in fluid communication with an analysis compartment wherein said body analyte acquired by said microdialysis needle may be assayed c) pumping means to move said perfusate from said reservoir into said inlet port of said microdialysis needle, through said microdialysis needle, out of said outlet port of said microdialysis needle, and into said analysis compartment d) a reservoir containing a body analyte calibration fluid in fluid communication with said analysis compartment e) pumping means to move said calibration fluid from said calibration fluid containing reservoir into said analysis compartment f) a reservoir containing a reagent solution in fluid communication with said analysis compartment g) pumping means to move said reagent solution from said reagent solution reservoir into said analysis compartment h) fluid sequencing means whereby the fluid moving into said analysis compartment may be selected as either said perfusate from said outlet port of said microdialysis needle mixed with said reagent solution or said calibration fluid mixed with said reagent solution.
-
17. A periodic body analyte monitoring device comprising
a) a microdialysis needle with an inlet port and an outlet port b) a reservoir containing a perfusate in fluid communication with said inlet port of said microdialysis needle c) the outlet port of said microdialysis needle in fluid communication with an analysis compartment wherein said body analyte may be assayed c) pumping means to move said perfusate from said perfusate reservoir into said inlet port of said microdialysis needle, through said microdialysis needle, and out of said outlet port of said microdialysis needle, and into said analysis compartment d) a reservoir containing a solution of an enzyme specific for said body analyte in fluid communication with said analysis compartment e) pumping means to move said enzyme solution from said enzyme solution reservoir into said analysis compartment f) a reservoir containing a body analyte calibration fluid in communication with said analysis compartment g) pumping means to move said calibration fluid from said calibration fluid containing reservoir into said analysis compartment h) fluid sequencing means whereby the fluid moving into said analysis compartment can be selected as either said perfusate mixed with said enzyme solution or said calibration fluid mixed with said enzyme solution.
- 30. A method of calibrating a body analyte monitoring microdialysis device comprising alternating the flow of a body analyte laden perfusate mixed with an appropriate reagent and a body analyte containing calibration fluid mixed with said appropriate reagent into an analysis compartment wherein a result of a reaction between said appropriate reagent and the body analyte in said body analyte containing perfusate or calibration fluid is measured.
Specification