Method and apparatus for optimizing ventricular synchrony during DDD resynchronization therapy using adjustable atrio-ventricular delays
First Claim
Patent Images
1. A system, comprising:
- a signal input to receive at least one cardiac signal indicative of cardiac events including at least one atrial event and one ventricular event;
an event detector, coupled to the signal input, to detect the at least one atrial event and one ventricular event;
a measurement module, coupled to the event detector, to measure an atrio-ventricular time interval (AV) between an atrial event and a ventricular event of the at least one atrial event and one ventricular event; and
an atrio-ventricular delay (AVD) calculator coupled to the measurement module, the AVD calculator adapted to calculate an AVD based on the AV to provide an approximately maximum positive rate of left ventricular pressure change during systole, LV+dp/dt, by delivering ventricular pacing pulses with the AVD.
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Abstract
A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchorny or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
274 Citations
25 Claims
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1. A system, comprising:
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a signal input to receive at least one cardiac signal indicative of cardiac events including at least one atrial event and one ventricular event;
an event detector, coupled to the signal input, to detect the at least one atrial event and one ventricular event;
a measurement module, coupled to the event detector, to measure an atrio-ventricular time interval (AV) between an atrial event and a ventricular event of the at least one atrial event and one ventricular event; and
an atrio-ventricular delay (AVD) calculator coupled to the measurement module, the AVD calculator adapted to calculate an AVD based on the AV to provide an approximately maximum positive rate of left ventricular pressure change during systole, LV+dp/dt, by delivering ventricular pacing pulses with the AVD. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method, comprising:
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delivering an atrial pacing pulse;
detecting an intrinsic ventricular event;
measuring an atrio-ventricular time interval (AV) between the delivery of the atrial pacing pulse and the ventricular event;
calculating an atrio-ventricular delay (AVD) based on the AV to provide an approximately maximum positive rate of left ventricular pressure change during systole, LV+dp/dt, by delivering ventricular pacing pulses with the AVD; and
delivering the ventricular pacing pulses with the AVD. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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18. A computer-readable medium having computer-executable instructions to cause a computer or computer-based system to perform a method comprising:
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receiving an atrio-ventricular time interval (AV) between an atrial event and a ventricular event; and
calculating an atrio-ventricular delay (AVD) based on the AV to provide an approximately maximum positive rate of left ventricular pressure change during systole, LV+dp/dt, by delivering ventricular pacing pulses with the AVD. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25)
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Specification