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System and methods for promoting expansion of polyclonal and antigen-specific cytotoxic T lymphocytes in response to artificial antigen presenting cells

  • US 20030147869A1
  • Filed: 01/03/2003
  • Published: 08/07/2003
  • Est. Priority Date: 01/03/2002
  • Status: Active Grant
First Claim
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1. An artificial antigen presenting cell (aAPC) for inducing rapid, long term proliferation of a population of T cells for research purposes, comprising a selected population of K562 cells engineered to express Fcγ

  • receptor CD32 (thereby creating K32 cells), transfected by a co-stimulatory ligand, then coating the K-32-ligand cells with anti-CD3 antibodies or anti-CD28 antibodies, or a combination thereof.

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