Modified carbon nanotubes as molecular labels with application to DNA sequencing
First Claim
1. A method of identifying molecules, comprising:
- modifying a detectable property of a nano-scale fullerene structure;
attaching the nano-scale fullerene structure to a reactive molecule;
selecting the nano-scale fullerene structure as a result of preferential interaction between the reactive molecule and a sample molecule;
placing the selected nano-scale fullerene structure on a substrate; and
analyzing a surface of the substrate based on the detectable property to detect the nano-scale fullerene structure.
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Abstract
A novel device and method for characterization of molecules is provides that improves characterization accuracy by utilizing larger numbers of reactive molecules that are smaller or shorter in chain length for the analysis procedure. Modification of markers such as nanotubes form nanotube assemblies that are easily detected using a number of surface analysis devices such as AFM and STM. The novel method shown using carbon nanotubes to mark a signature on reactive molecules permits a larger distribution and smaller molecule size of reactive molecules used in characterization of a sample molecule. The modification of the carbon nanotubes allows the characterization procedure to detect the nanotube markers more easily, thus decreasing characterization errors, and allowing faster characterization speeds.
24 Citations
31 Claims
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1. A method of identifying molecules, comprising:
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modifying a detectable property of a nano-scale fullerene structure;
attaching the nano-scale fullerene structure to a reactive molecule;
selecting the nano-scale fullerene structure as a result of preferential interaction between the reactive molecule and a sample molecule;
placing the selected nano-scale fullerene structure on a substrate; and
analyzing a surface of the substrate based on the detectable property to detect the nano-scale fullerene structure. - View Dependent Claims (2, 3)
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4. A method of identifying molecules, comprising:
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modifying a friction coefficient of a carbon nanotube;
attaching the carbon nanotube to a reactive molecule;
selecting the carbon nanotube as a result of preferential interaction between the reactive molecule and a sample molecule;
placing the selected carbon nanotube on a substrate; and
measuring friction characteristics of the substrate to detect the carbon nanotube. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of identifying molecules, comprising:
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modifying electrical properties of a carbon nanotube;
attaching the carbon nanotube to a reactive molecule;
selecting the carbon nanotube as a result of preferential interaction between the reactive molecule and a sample molecule;
placing the selected carbon nanotube on a substrate; and
detecting the carbon nanotube using electrical surface detection techniques. - View Dependent Claims (15, 16, 17)
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18. A molecular identification assembly, comprising:
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a reactive molecule;
a carbon nanotube attached to the reactive molecule; and
a chemical modifier attached to the carbon nanotube, the chemical modifier altering the friction coefficient of the carbon nanotube. - View Dependent Claims (19, 20, 21, 22, 23)
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24. A method of forming a molecular identification assembly, comprising:
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modifying a friction coefficient of a carbon nanotube; and
attaching the carbon nanotube to a reactive molecule. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31)
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Specification