DNA capillary
First Claim
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1. A DNA capillary comprising:
- at least one fluid passageway having at least a part thereof defined by a wall which transmits light and having a uniform width and height large enough to allow at least a required amount of a processing liquid to flow therethrough;
a plurality of independent probe regions formed in an inner wall of said fluid passageway; and
a plurality of DNA probes each immobilized in said independent probe regions, wherein said fluid passageway comprises a hollow capillary, and said DNA probes immobilized in said probe regions are arranged independently along the fluid passageway.
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Abstract
The present invention relates to an apparatus for detecting nucleic acid molecules such as target DNA molecules and mRNA molecules by using a DNA probe, and provides a DNA capillary, comprising a fluid passageway formed of a cylindrical capillary made of glass, a plurality of independent probe regions formed in the inner wall of the fluid passageway, and DNA probes each immobilized in the probe region, the immobilized DNA probes differing from each other. For performing the measurement, a sample is introduced through an open portion into the capillary so as to perform reaction and, then, fluorimetry.
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Citations
24 Claims
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1. A DNA capillary comprising:
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at least one fluid passageway having at least a part thereof defined by a wall which transmits light and having a uniform width and height large enough to allow at least a required amount of a processing liquid to flow therethrough;
a plurality of independent probe regions formed in an inner wall of said fluid passageway; and
a plurality of DNA probes each immobilized in said independent probe regions, wherein said fluid passageway comprises a hollow capillary, and said DNA probes immobilized in said probe regions are arranged independently along the fluid passageway. - View Dependent Claims (3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23)
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2. A DNA capillary comprising:
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at least one tubular fluid passageway defined by a wall capable of transmitting light in at least a part thereof, said fluid passageway extending straight on the substrate in the longitudinal direction, the cross sectional area of said fluid passageway along a plane perpendicular to the fluid flowing direction being constant over the entire length of a processing region of said fluid passageway, and the processing region of said fluid passageway producing a capillary function; and
a plurality of kinds of DNA probes formed in the inner wall of said fluid passageway, said DNA probes being immobilized circular in a manner to make one complete rotation along the inner wall of said fluid passageway in a predetermined amount for each kind and independently from each other depending on the kind. - View Dependent Claims (4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24)
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Specification