Method for vascular occlusive therapy in gastrointestinal system

• US 20030149335A1
• Filed: 03/06/2003
• Published: 08/07/2003
• Est. Priority Date: 12/11/1998
• Status: Active Grant

• Current Assignee: Alan Stein, David E. Silverman
• Original Assignee: Alan Stein, David E. Silverman
• Inventors: Stein, Alan, Silverman, David E.
• Granted Patent: US 7,249,601 B2
• Time in Patent Office: Days
• US Class Current: 600/29
• CPC Class Codes: A61B 1/00133 Drive units for endoscopic tools inserted through or with the endoscope
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/1204 temporary occlusion
• CPC Class Codes: A61B 17/12045 double occlusion, e.g. during anastomosis
• CPC Class Codes: A61B 17/12099 characterised by the location of the occluder
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/00269 endoscopic mucosal resection EMR
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61F 2/0036 implantable A61F2/0018 takes precedence
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

A method for treating a blood vessel in a wall forming a gastrointestinal tract of a body of a mammal. At least one nonaqueous solution is introduced from the gastrointestinal tract into the vessel. A nonbiodegradable solid is formed in the vessel in the vicinity of a portion of the vessel from the least one nonaqueous solution to create an occlusion in the vessel and thus terminate blood flow to the vessel distal of the occlusion.

Claims

1. A method for use in a body of a mammal having an internal wall forming a gastrointestinal tract to treat a blood vessel in the wall having a portion comprising the steps of introducing at least one nonaqueous solution from the gastrointestinal tract into the vessel and forming from the at least one nonaqueous solution a nonbiodegradable solid in the vessel in the vicinity of the portion to create an occlusion in the vessel and thus terminate blood flow to the vessel distal of the occlusion.

2. The method of claim 1 wherein the at least one solution is a solution of a biocompatible polymer and a biocompatible solvent and wherein the forming step includes the step of precipitating the biocompatible polymer from the solution so that the biocompatible polymer solidifies in the vessel and the biocompatible solvent disperses in the body.

3. The method of claim 2 wherein the solution of the biocompatible polymer and the biocompatible solvent has a composition comprising from about 2.5 to about 8.0 weight percent of a biocompatible polymer, from about 10 to about 40 weight percent of a water insoluble biocompatible contrast agent and from about 52 to about 87.5 weight percent of a biocompatible solvent.

4. The method of claim 2 wherein the solution of the biocompatible polymer and the biocompatible solvent has a composition comprising from about 2.5 to about 8.0 weight percent of a biocompatible polymer, from about 10 to about 40 weight percent of a water soluble biocompatible contrast agent and from about 52 to about 87.5 weight percent of a biocompatible solvent.

5. The method of claim 2 wherein the introducing step includes the steps of extending a needle into vessel and supplying the biocompatible polymer and the biocompatible solvent through the needle into the vessel.

6. The method of claim 5 wherein the introducing step includes the step of introducing the needle through the mouth and into the gastrointestinal tract.

7. The method of claim 6 wherein the portion of the vessel is an enlarged varix in the vicinity of the gastroesophageal sphincter.

8. The method of claim 6 wherein the portion of the vessel is an ulcer in the gastrointestinal tract.

9. The method of claim 5 wherein the introducing step includes the step of introducing the needle through the anus and into the anal canal of the gastrointestinal tract.

10. The method of claim 9 wherein the portion of the vessel is a hemorrhoid in the anal canal.

11. The method of claim 1 wherein the portion of the vessel is an enlarged varix in the vicinity of the gastroesophageal sphincter.

12. The method of claim 1 wherein the portion of the vessel is an ulcer.

13. The method of claim 12 further comprising the step of forming at least one implant in the wall in the vicinity of the gastrointestinal tract to create a tamponade.

14. The method of claim 1 wherein the portion of the vessel is a hemorrhoid in the anal canal.

15. The method of claim 1 wherein the mammal is a human.

16. The method of claim 1 further comprising the step of ligating the portion of the vessel.

17. The method of claim 1 further comprising the step of introducing a clotting agent into the vessel in the vicinity of the portion.

18. The method of claim 1 further comprising the step of cauterizing the vessel in the vicinity of the portion.