Coated vascular prosthesis and methods of manufacture and use
First Claim
1. A method for making a vascular prosthesis comprising the steps of:
- providing a crimped substrate, the substrate comprising a woven or knitted polymer fabric, the substrate having a first surface and a second surface opposite the first surface, the second surface being a blood interface surface;
coating the first surface with a first solution, the first solution comprising a first polymer and a particulate in a first solvent;
allowing the first solution to dry, thereby forming a first coat on the substrate;
coating the first coat with a second solution, the second solution comprising a second polymer in a second solvent; and
immersing the coated substrate in a third solvent to precipitate the second polymer from solution, thereby forming a porous second coat.
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Accused Products
Abstract
A method for forming a kink resistant, blood impermeable graft comprises the steps of: providing a crimped substrate of polymer fabric; coating the outer surface of the substrate with a first solution comprising a first polymer and a particulate in a first solvent; allowing the first solution to dry, thereby forming a first coat on the substrate; coating the first coat with a second solution comprising a second polymer in a second solvent; and immersing the coated substrate in a third solvent to precipitate the second polymer from solution, thereby forming a porous second coat. The third solvent also dissolves the salt in the first coat to form pores in the first coat. The first and second polymer solutions do not penetrate to the interior surface of the substrate of the graft. Vascular prostheses made by this method are blood impermeable and kink resistant and are particularly useful as outflow cannulas for ventricular assist devices.
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Citations
48 Claims
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1. A method for making a vascular prosthesis comprising the steps of:
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providing a crimped substrate, the substrate comprising a woven or knitted polymer fabric, the substrate having a first surface and a second surface opposite the first surface, the second surface being a blood interface surface;
coating the first surface with a first solution, the first solution comprising a first polymer and a particulate in a first solvent;
allowing the first solution to dry, thereby forming a first coat on the substrate;
coating the first coat with a second solution, the second solution comprising a second polymer in a second solvent; and
immersing the coated substrate in a third solvent to precipitate the second polymer from solution, thereby forming a porous second coat. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for sealing the pores of a fabric graft comprising the steps of:
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applying a first solution to a first surface of the graft, the first solution comprising a polyurethane and a salt in a first solvent;
allowing the first solution to dry, thereby forming a first coat on the graft;
applying a second solution to the coated first surface, the second solution comprising a second polyurethane in a second solvent; and
immersing the coated graft in water to precipitate the second polyurethane from solution, thereby forming a porous second coat, and dissolving the salt in the first coat to form pores in the first coat. - View Dependent Claims (21, 22, 23, 24)
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25. A vascular prosthesis comprising:
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a substrate comprising a crimped woven or knitted polymer fabric, the substrate having a first surface and a second surface opposite the first surface, the second surface being a blood interface surface;
a first porous coating disposed on the first surface, the first porous coating comprising a first polymer; and
a second porous coating disposed on the first porous coating, the second porous coating comprising a second polymer, and wherein the first coating does not penetrate to the second surface of the substrate. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A vascular prosthesis comprising:
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a first layer comprising a crimped woven or knitted polymer fabric having a first surface;
a second layer comprising a first porous coating disposed on the first surface, the first porous coating comprising a first polymer; and
a third layer comprising a second porous coating disposed on the first porous coating, the second porous coating comprising a second polymer, and wherein the second layer is disposed between the first and third layers, and wherein the first porous coating does not penetrate to a second surface of the first layer. - View Dependent Claims (39, 40)
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41. A method for providing cardiac support in an individual comprising implanting a ventricular assist device in the individual, the ventricular assist device comprising an outflow graft, the outflow graft comprising:
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a substrate comprising a crimped woven or knitted polymer fabric, the substrate having a first surface and a second surface opposite the first surface, the second surface being a blood interface surface;
a first porous coating disposed on the first surface, the first porous coating comprising a first polymer; and
a second porous coating disposed on the first porous coating, the second porous coating comprising a second polymer, and wherein the first coating does not penetrate to the second surface of the substrate. - View Dependent Claims (42, 43, 44)
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45. A method for repairing a defective vessel in an individual comprising reinforcing or replacing the defective vessel with a vascular graft comprising:
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a substrate comprising a crimped woven or knitted polymer fabric, the substrate having a first surface and a second surface opposite the first surface, the second surface being a blood interface surface;
a first porous coating disposed on the first surface, the first porous coating comprising a first polymer; and
a second porous coating disposed on the first porous coating, the second porous coating comprising a second polymer, and wherein the first coating does not penetrate to the second surface of the substrate. - View Dependent Claims (46, 47, 48)
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Specification