Composition for treating contact lenses

• US 20030153475A1
• Filed: 12/09/2002
• Published: 08/14/2003
• Est. Priority Date: 12/20/2001
• Status: Abandoned Application

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Hu, Zhenze, Simpson, Lisa C., Lever, Andrea
• Application Number:
  US10/314,753
• Publication Number:
  US 20030153475A1
• Time in Patent Office: Days
• US Class Current: 510/112
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 12/08 using chemical substances
• CPC Class Codes: A61L 12/14 Organic compounds not covered by groups A61L12/10 or A61L12/12
• CPC Class Codes: A61L 12/141 Biguanides, e.g. chlorhexidine
• CPC Class Codes: A61L 12/143 Quaternary ammonium compounds
• CPC Class Codes: C11D 1/008 Polymeric surface-active agents
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/30 Amines; Substituted amines ; Quaternized amines
• CPC Class Codes: C11D 7/3218 Alkanolamines or alkanolimines

Abstract

A method for cleaning contact lenses employs a composition that includes tromethamine in an amount effective to reduce the amount of denatured protein on the contact lens, thus rendering the contact lenses easier to clean. Additionally, by soaking contact lenses in the composition prior to inserting the lens on the eye, the compositions provide a prophylactic effect in preventing protein denaturation while the contact lens is worn.

Claims

1. A method of reducing denatured proteins on a contact lens, comprising soaking the contact lens in an aqueous composition that comprises tromethamine in an amount effective to reduce the amount of denatured protein on the contact lens.

2. The method of claim 1, wherein the composition further comprises at least one member selected from the group consisting of an antimicrobial agent, a buffering agent, a chelating agent, an osmolality adjusting agent, and a surfactant.

3. The method of claim 1, wherein the composition further comprises an antimicrobial agent in an amount effective to disinfect the contact lens, said amount being an amount effective in the absence of tromethamine.

4. The method of claim 3, wherein the composition comprises 0.05 to 0.5 weight percent of tromethamine

5. The method of claim 4, wherein the composition further comprises a chelating agent, and a buffering agent selected from the group consisting borate buffers, phosphate buffers and citrate buffers.

6. The method of claim 5, wherein the composition further comprises a surfactant.

7. The method of claim 6, wherein the composition comprises at least one member selected from the group consisting of poloxamer and poloxamine surfactants.

8. A method of preventing deposition of denatured proteins on a contact lens while worn on the eye, comprising soaking the contact lens in an aqueous composition, and inserting the contact lens in the eye without rinsing the composition from the contact lens, wherein the composition comprises tromethamine in an amount effective to prevent denaturation of proteins in the eye.

9. The method of claim 8, wherein the composition further comprises at least one member selected from the group consisting of an antimicrobial agent, a buffering agent, a chelating agent, an osmolality adjusting agent, and a surfactant.

10. The method of claim 8, wherein the composition further comprises an antimicrobial agent in an amount effective to disinfect the contact lens, said amount being an amount effective in the absence of tromethamine.

11. The method of claim 10, wherein the composition comprises 0.05 to 0.5 weight percent of tromethamine

12. The method of claim 11, wherein the composition further comprises a chelating agent, and a buffering agent selected from the group consisting borate buffers, phosphate buffers and citrate buffers.

13. The method of claim 12, wherein the composition further comprises a surfactant.

14. The method of claim 13, wherein the composition comprises at least one member selected from the group consisting of poloxamer and poloxamine surfactants.

15. A method of cleaning a contact lens, comprising soaking the contact lens in an aqueous composition that comprises tromethamine in an amount effective to reduce the amount of denatured protein on the contact lens, and rinsing the contact lens to remove proteins.

16. The method of claim 15, wherein the proteins are removed without manual rubbing.

17. The method of claim 15, wherein the contact lens is rinsed with said solution and then inserted directly into the eye.

18. The method of claim 15, wherein the composition includes an antimicrobial agent, and the contact lens is disinfected while soaked in the aqueous composition.

19. The method of claim 18, wherein the antimicrobial agent is present in an amount effective to disinfect the contact lens, said amount being an amount effective in the absence of tromethamine.