Fluidic device for medical diagnostics
First Claim
1. A fluidic diagnostic device for measuring an analyte concentration or property of a biological fluid, comprising a first layer and second layer, at least one of which has a resilient region over at least a part of its area, separated by an intermediate layer, in which cutouts in the intermediate layer form, with the first and second layers, a) a sample port for introducing a sample of the biological fluid into the device;
- b) a first measurement area, in which a physical parameter of the sample is measured and related to the analyte concentration or property of the fluid;
c) a first channel, having a first end and a second end, to provide a fluidic path from the sample port at the first end through the first measurement area;
d) a first bladder, at the second end of the first channel, comprising at least a part of the resilient region in at least the first or second layer and having a volume that is at least about equal to the combined volume of the first measurement area and first channel; and
e) a first stop junction in the first channel between the first measurement area and first bladder that comprises a co-aligned through hole in the first or second layer, the through hole overlaid with a third layer.
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Accused Products
Abstract
A fluidic medical diagnostic device permits measurement of analyte concentration or a property of a biological fluid, particularly the coagulation time of blood. The device has at one end a sample port for introducing a sample and at the other end a bladder for drawing the sample to a measurement area. A channel carries the sample from the sample port to the measurement area, and a stop junction, between the measurement area and bladder, halts the sample flow. The desired measurement can be made by placing the device into a meter which measures a physical property of the sample—typically, optical transmittance—after it has interacted with a reagent in the measurement area.
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Citations
21 Claims
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1. A fluidic diagnostic device for measuring an analyte concentration or property of a biological fluid, comprising
a first layer and second layer, at least one of which has a resilient region over at least a part of its area, separated by an intermediate layer, in which cutouts in the intermediate layer form, with the first and second layers, a) a sample port for introducing a sample of the biological fluid into the device; -
b) a first measurement area, in which a physical parameter of the sample is measured and related to the analyte concentration or property of the fluid;
c) a first channel, having a first end and a second end, to provide a fluidic path from the sample port at the first end through the first measurement area;
d) a first bladder, at the second end of the first channel, comprising at least a part of the resilient region in at least the first or second layer and having a volume that is at least about equal to the combined volume of the first measurement area and first channel; and
e) a first stop junction in the first channel between the first measurement area and first bladder that comprises a co-aligned through hole in the first or second layer, the through hole overlaid with a third layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A fluidic diagnostic device for measuring an analyte concentration or property of a biological fluid, comprising
a first layer, which has a resilient region over at least a part of its area, and a second layer, separated by an intermediate layer, in which recesses in a first surface of the intermediate layer form, with the first layer, a) a sample port for introducing a sample of the biological fluid into the device; -
b) a measurement area, in which the sample undergoes a change in a physical property that is measured and related to the analyte concentration or property of the fluid;
c) a channel, having a first end and a second end, to provide a fluidic path from the sample port at the first end through the measurement area; and
d) a bladder, at the second end of the channel, comprising the resilient region in the first layer and having a volume that is at least about equal to the combined volume of the measurement area and channel; and
a stop junction in the channel between the measurement area and bladder that comprises two passages substantially normal to the first surface of the intermediate layer, each passage having a first end in fluid communication with the channel and a second end in fluid communication with a recess in a second surface of the intermediate layer, which recess provides fluid communication between the second ends of the passages.
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Specification