Optomechanically-responsive materials for use as light-activated actuators and valves

• US 20030156991A1
• Filed: 10/22/2002
• Published: 08/21/2003
• Est. Priority Date: 10/23/2001
• Status: Abandoned Application

• Current Assignee: Rice University
• Original Assignee: Rice University
• Inventors: Sershen, Scott R., West, Jennifer, Halas, Nancy J.
• Application Number:
  US10/277,852
• Publication Number:
  US 20030156991A1
• Time in Patent Office: Days
• US Class Current: 422/100
• CPC Class Codes: B01L 2400/0661 shape memory polymer valves
• CPC Class Codes: B01L 2400/0677 phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: F16K 2099/0074 using photolithography, e.g. etching
• CPC Class Codes: F16K 2099/0078 using moulding or stamping
• CPC Class Codes: F16K 2099/0084 Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 99/0001 Microvalves microdevices B81B1/00; manufacture or treatment of devices or systems in or on a substrate B81C1/00; microfluidic structures B01L3/5027; micropumps F04B19/006
• CPC Class Codes: F16K 99/0034 Operating means specially adapted for microvalves
• CPC Class Codes: F16K 99/0036 operated by temperature variations
• CPC Class Codes: F16K 99/004 using radiation

Abstract

The present invention provides a photoactuator comprising a plurality of nanoparticles and a thermally sensitive material. The photoactuator is useful for a variety of applications including macroscale and nanoscale applications. The nanoparticles are in thermal contact with the thermally sensitive material. The nanoparticles are engineered to achieve peak resonance at a given wavelength of light such that upon illumination. Upon illumination of the thermally sensitive material, the nanoparticles convert the light to heat, which is transferred to the thermally sensitive material, inducing a change in volume in the thermally sensitive material. The present invention is useful for actuating devices, especially in microfluidic devices. Methods for making a photoactuator and various embodiments thereof are also provided.

Claims

1. A photo actuator comprising:

a plurality of nanoparticles designed to resonate at a predetermined wavelength of light; and

a medium, said plurality of nanoparticles being in thermal contact with said medium and said medium comprising a thermally sensitive material, wherein said medium actuates a device by physical movement of said medium in response to light at said predetermined wavelength.

2. The photoactuator according to claim 1 wherein said nanoparticles comprise nanoshells.

3. The photoactuator according to claim 1 wherein said nanoparticles comprise metal colloid.

4. The photoactuator according to claim 1 wherein said medium is a hydrogel.

5. The photoactuator according to claim 4 wherein said medium comprises a N-isopropylacrylamide polymer.

6. The photoactuator according to claim 1 wherein said device is a valve.

7. The photoactuator according to claim 1 wherein said device is a pump.

8. The photoactuator according to claim 1 wherein said plurality of nanoparticles are dispersed in said medium.

9. A method for making a photoactuator in a void space comprising the steps of:

(a) mixing a plurality of nanoparticles and a monomer, said monomer being capable of forming a thermally sensitive material upon polymerization;

(b) filling said void space with said plurality of nanoparticles and said monomer; and

(c) inducing polymerization of said monomer such tat said monomer polymerizes to form said thermally responsive material within said void space and encompasses at least some of said plurality of nanoparticles.

10. The method according to claim 9 wherein step (a) further comprises mixing a photoinitiator and a crosslinker with said plurality of nanoparticles and said monomer, wherein step (b) further comprises filling said void space with said photoinitiator and said crosslinker, and wherein step (c) comprises illuminating said plurality of nanoparticles, said photoinitiator, said crosslinker, and said monomer with ultraviolet light, such that said monomer polymerizes to form said thermally responsive material and encompasses at least some of said plurality of nanoparticles.

11. The method according to claim 10 wherein said void space comprises a microfluidic channel with a post and wherein step (c) comprises polymerizing said monomer around said post.

12. The method according to claim 11 wherein step (c) further comprises placing a mask over said channel, said mask having a hole in a desired shape of said photoactuator and said ultraviolet light passing through said hole to form said thermally responsive material in said desired shape.

13. The method according to claim 10 wherein step (a) is performed before step (b).

14. The method according to claim 9 wherein said plurality of nanoparticles comprises a plurality of nanoshells.

15. The method according to claim 9 wherein said plurality of nanoparticles comprises metal colloid.

16. The method according to claim 9 wherein said thermally sensitive material comprises a hydrogel.

17. The method according to claim 16 wherein said monomer comprises N-isopropylacrylamide.

18. A microfluidic device comprising:

a substrate;

at least one channel etched into said substrate for directing a flow; and

a first photoactuated device located on said substrate and designed to control said flow.

19. The microfluidic device according to claim 18 wherein said first photoactuated device comprises a plurality of nanoparticles in thermal contact with a thermally responsive medium.

20. The microfluidic device according to claim 19 wherein said plurality of nanoparticles are dispersed in said thermally sensitive medium.

21. The microfluidic device according to claim 19 wherein said plurality of nanoparticles comprise nanoshells.

22. The microfluidic device according to claim 19 wherein said plurality of nanoparticles comprise metal colloid.

23. The microfluidic device according to claim 19 wherein said first photoactuated device comprises a pump.

24. The microfluidic device according to claim 19 wherein said first photoactuated device comprises a valve.

25. The microfluidic device according to claim 19 wherein said thermally sensitive medium comprises a hydrogel.

26. The microfluidic device according to claim 25 wherein said thermally responsive medium comprises a N-isopropylacrylamide polymer.

27. The microfluidic device according to claim 18 further comprising:

a second photoactuated device located on said substrate.

28. The microfluidic device according to claim 27 wherein said first photoactuated device comprises a first plurality of nanoparticles designed to achieve peak resonance at a first wavelength of light and wherein said second photoactuated device comprises a second plurality of nanoparticles designed to achieve peak resonance at a second wavelength of light.

29. The microfluidic device according to claim 28 wherein said first and said second wavelengths are different.

30. The microfluidic device according to claim 28 wherein said first and said second wavelengths are nearly the same.

31. A photoactuated valve comprising:

a thermally responsive material, said thermally responsive material connected to and disposed in a channel; and

a plurality of nanoparticles dispersed in said thermally responsive material, said plurality of nanoparticles being designed to resonate at a predetermined wavelength of light.

32. The photoactuated valve according to claim 31 wherein said thermally responsive material comprises a hydrogel.

33. The photoactuated valve according to claim 32 wherein said thermally responsive material comprises a N-isopropylacrylamide polymer.

34. The photoactuated valve according to claim 31 wherein said channel is disposed on a microfluidic device.

35. The photoactuated valve according to claim 31 wherein said plurality of nanoparticles comprises a plurality of nanoshells.

36. The photoactuated valve according to claim 31 wherein said plurality of nanoparticles comprises a plurality of metal colloid particles.

37. A method for producing a photoactuated valve comprising the steps of:

(a) mixing a plurality of nanoparticles, a crosslinker, a photoinitiator, and a monomer;

(b) injecting said plurality of nanoparticles, said crosslinker, said photoinitiator, and said monomer into a channel; and

(c) illuminating said monomer, said crosslinker, said photoinitiator, and said plurality of nanoparticles with ultraviolet light such that said monomer polymerizes to form a thermally responsive material that encompasses at least some of said plurality of nanoparticles.

38. The method according to claim 37 wherein said plurality of nanoparticles comprises a plurality of metal colloid particles.

39. The method according to claim 37 wherein said plurality of nanoparticles comprises a plurality of nanoshells.

40. The method according to claim 37 wherein said monomer comprises N-isopropylacrylamide.

41. The method according to claim 40 wherein said monomer further comprises acrylamide.

42. The method according to claim 37 wherein said channel is disposed on a microfluidic device.

43. The method according to claim 37 further comprising performing step (a) before step (b).

44. The method according to claim 37 wherein said channel comprises a post and wherein step (c) further comprises illuminating said monomer, said crosslinker, said photoinitiator, and said plurality of nanoparticles with ultraviolet light such that said monomer polymerizes to form a thermally sensitive material that is connected to said post.