Method for determining hemodynamic state

• US 20030158493A1
• Filed: 02/12/2003
• Published: 08/21/2003
• Est. Priority Date: 03/13/2000
• Status: Abandoned Application

• Current Assignee: N.I. Medical Ltd.
• Original Assignee: N.I. Medical Ltd.
• Inventors: Cotter, Gad, Goor, Daniel, Moshkovitz, Yaron
• Application Number:
  US10/221,764
• Publication Number:
  US 20030158493A1
• Time in Patent Office: Days
• US Class Current: 600/513
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

A method for determining the hemodynamic state of a subject. The method comprises (a) determining the cardiac power index (Cpi) and systemic vascular resistance index (SVRi) values of a plurality of patients who have been diagnosed as having a specified hemodynamic state; (b) determining the range of Cpi and SVRi paired values corresponding to each of the hemodynamic states; (c) determining the Cpi and SVRi paired value of the subject; (d) comparing the Cpi and SVRi paired value of the subject to the ranges of Cpi and SVRi paired values determined in step (b); and (e) determining the range of Cpi and SVRi paired values which is most similar to the Cpi and SVRi paired value of the subject. The hemodynamic state which corresponds to the range indicates the hemodynamic state of the subject.

Claims

1. A method for determining the hemodynamic state of a subject comprising:

(a) determining the cardiac power index (Cp_i) and systemic vascular resistance index (SVR_i) values of a plurality of patients who have been diagnosed as having a hemodynamic state selected from the group consisting of systolic congestive heart failure (sCHF), pulmonary edema (PE), cardiogenic shock (CS), vasodilative shock (VS) and normal state;

(b) determining the range of Cp_i and SVR_i paired values corresponding to each of said hemodynamic states;

(c) determining the Cp_i and SVR_i paired value of said subject;

(d) comparing the Cp_i and SVR_i paired value of said subject to the ranges of Cp_i and SVR_i paired values determined in step (b); and

(e) determining the range of Cp_i and SVR_i paired values which is most similar to the Cp_i and SVR_i paired value of said subject, the hemodynamic state corresponding to said range indicating the hemodynamic state of said subject.

2. A method according to claim 1 wherein said Cp_i and SVR_i paired values are plotted on a graph, and said range of Cp_i and SVR_i paired values indicative of each of said hemodynamic states is indicated by a delineated area on said graph.

3. A method according to claim 2 wherein said graph is substantially equivalent to FIG. 5.

4. A method according to claim 1 wherein said ranges of Cp_i and SVR_i paired values indicative of each of said hemodynamic states are calculated by statistical analysis and said Cp_i and SVR_i values of said subject are compared to said ranges by a statistical method.

5. A method according to claim 4 wherein said range of Cp_i and SVR_i paired values indicative of each of said hemodynamic states is displayed in a graph format on a display screen.

6. A method according to claim 1 wherein Cp_i is calculated from the product of the cardiac index (CI) and the mean arterial blood pressure (MAP).

7. A method according to claim 6 wherein said cardiac index and/or said blood pressure is measured by an invasive measuring technique.

8. A method according to claim 7 wherein said measuring technique for measuring the cardiac output employs a Swan-Ganz catheter.

9. A method according to claim 1 wherein cardiac output and/or said blood pressure is measured by a non-invasive measuring technique.

10. A method of monitoring the hemodynamic state of a subject, comprising:

(a) determining the Cp_i and SVR_i of said subject;

(b) determining the hemodynamic state of said subject by the method of claim 1;

(c) redetermining the Cp_i and SVR_i of said subject after a predetermined time;

(d) redetermining the hemodynamic state of said subject by the method of claim 1;

and

(e) comparing the hemodynamic state obtained in steps (b) and (d).

11. A method of assessing the effect of a medical treatment on the hemodynamic state of a subject, comprising:

(a) determining the Cp_i and SVR_i of said subject;

(b) determining the hemodynamic state of said subject by the method of claim 1;

(c) administering said medical treatment to said subject;

(d) determining the Cp_i and SVR_i of said subject after said treatment;

(e) determining the hemodynamic state of said subject by the method of claim 1;

and

(f) comparing the hemodynamic state obtained in steps (b) and (e).

12. An apparatus for determining the hemodynamic state of a subject, comprising:

(a) means for determining the cardiac power index (Cp_i) and systemic vascular resistance index (SVR_i) values of a plurality of patients who have been diagnosed as having a hemodynamic state selected from the group consisting of systolic congestive heart failure (sCHF), pulmonary edema (PE), cardiogenic shock (CS), vasodilative shock (VS) and normal state;

(b) means for determining the range of Cp_i and SVR_i paired values corresponding to each of said hemodynamic states;

(c) means for determining the Cp_i and SVR_i paired value of said subject;

(d) means for comparing the Cp_i and SVR_i paired value of said subject to the ranges of Cp_i and SVR_i paired values determined by the means of (b); and

(e) means for determining the range of Cp_i and SVR_i paired values which is most similar to the Cp_i and SVR_i paired value of said subject, the hemodynamic state corresponding to said range indicating the hemodynamic state of said subject.

13. An apparatus according to claim 12 wherein said means is a computer.

14. An apparatus according to claim 12 wherein said Cp_i and SVR_i paired values are plotted on a graph and said range of Cp_i and SVR_i paired values indicative of each of said hemodynamic states is indicated by a delineated area on said graph.

15. An apparatus according to claim 14 wherein said graph is substantially equivalent to FIG. 5.

16. An apparatus according to claim 12 wherein said ranges of Cp_i and SVR_i paired values indicative of each of said hemodynamic states are calculated by statistical analysis and said Cp_i and SVR_i values of said subject are compared to said ranges by a statistical method.

17. An apparatus according to claim 16 wherein said range of Cp_i and SVR_i paired values indicative of each of said hemodynamic states is displayed in a graph format on a display screen.

18. An apparatus according to claim 12 wherein Cp_i is calculated from the product of the cardiac index (CI) and the mean arterial blood pressure (MAP).

19. An apparatus according to claim 18 wherein said cardiac index and/or said blood pressure is measured by an invasive measuring technique.

20. An apparatus according to claim 19 wherein said measuring technique for measuring the cardiac output employs a Swan-Ganz catheter.

21. An apparatus according to claim 12 wherein cardiac output and/or said blood pressure is measured by a non-invasive measuring technique.

22. An apparatus according to claim 12 for monitoring the hemodynamic state of a subject, comprising means for following the change in position of the paired Cp_i and SVR_i values of the patient with respect to the predetermined set of values over a predetermined period of time, thereby monitoring the hemodynamic state of said subject over said period of time.