Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products
First Claim
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1. A composition, comprising animal cells producing essential fatty acids.
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Abstract
The invention generally relates to synthesis of essential fatty acids and their derivatives, long-chain polyunsaturated fatty acids (LC-PUFAs) and eicosanoids in transfected cells and in transgenic animals.
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31 Claims
- 1. A composition, comprising animal cells producing essential fatty acids.
- 10. A composition, comprising transfected animal cells, said transfected animal cells producing altered levels of long-chain polyunsaturated fatty acids relative to the animal cells prior to transfection.
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19. A method, comprising:
- a) providing;
i) a non-human animal cell, ii) a vector comprising nucleic acid encoding a heterologous desaturase, and iii) a recipient non-human female animal;
b) introducing said vector into said cell to create a transfected cell; and
c) transferring said transfected cell into said recipient female under conditions such that at least one offspring is produced, said offspring expressing said desaturase in one or more tissues. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
- a) providing;
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31. A transgenic non-human animal, said animal producing at least one product, said product selected from the group consisting of arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid.
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