Anti-dandruff and anti-itch compositions containing sensate and sensate enhancer-containing compounds

• US 20030161802A1
• Filed: 02/05/2002
• Published: 08/28/2003
• Est. Priority Date: 02/05/2002
• Status: Abandoned Application

• Current Assignee: International Flavors & Fragrances Incorporated
• Original Assignee: International Flavors & Fragrances Incorporated
• Inventors: Boden, Richard M., Christensen, Carol, Grainger, Brian T., Flammer, Linda J.
• Application Number:
  US10/067,596
• Publication Number:
  US 20030161802A1
• Time in Patent Office: Days
• US Class Current: 424/70.1
• CPC Class Codes: A61K 2800/244 Endothermic; Cooling; Cooling sensation
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 Liliopsida [monocotyledons]
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 17/00 Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair

Abstract

Described are anti-dandruff and anti-itch compositions comprising:

(a) an antidandruff agent;

(b) a cooling sensate material; and

(c) a cooling sensate.

Also described are personal care products for reduction of itching including shampoos, soaps, ointments and creams which contain the anti-dandruff and anti-itch compositions.

Claims

1. An anti-dandruff composition comprising:

(a) an anti-dandruff agent;

(b) a cooling sensate material; and

(c) a cooling sensate enhancer material.

2. The anti-dandruff composition of claim 1 wherein the cooling sensate enhancer material is selected from the group consisting of vanillyl C₂-C₈ alkyl ether, a menthoxymethyl dihydroxyphenyl dioxolane, a menthoxymethyl hydroxymethoxyphenyl dioxolane, a C₇-C₁₂ alkanoic acid vanillamide, a vanillin or ethyl vanillin C₃-C₆ alkylene glycol acetal, ginger oleoresin, capsicum oleoresin, and capsaicin.

3. The anti-dandruff composition of claim 1 wherein the cooling sensate material is selected from the group consisting of a hydroxy-lower alkyl derivative of para-menthane, 1-isopulegol, mint oil, spearmint oil, peppermint oil, methyl salicylate, menthone, menthone glyceryl ketal, menthol, p-menthane diol, menthyl lactate, mono-menthyl succinate, an alkali metal salt of mono-menthyl succinate, an alkaline earth metal salt of mono-menthyl succinate, mono-menthyl glutarate, an alkali metal salt of mono-menthyl glutarate, a menthoxy-C₁-C₅ alkanol, a menthoxy C₁-C₅ alkyl ether, a C₁-C₃ alkyl or dialkyl-N-substituted menthane carboxamide, a menthoxy-C₁-C₅ alkanediol, a C₁-C₃ alkyl or dialkyl-N-substituted C₅-C₁₂ alkyl carboxamide, an alkyl cyclohexyl sulfone, an alkyl cyclohexyl sulfoxide and a cyclic α

-keto enamine.

4. The anti-dandruff composition of claim 2 wherein the cooling sensate enhancer is selected from the group consisting of a vanillyl C₂-C₈ alkyl ether, a menthoxymethyl dihydroxyphenyl dioxolane, a menthoxymethyl hydroxymethoxyphenyl dioxolane, a C₇-C₁₂ alkanoic acid vanillamide, a vanillin or ethyl vanillin C₃-C₆ alkylene glycol acetal, ginger oleoresin, capsicum oleoresin, capsaicin, Jambu oleoresin, Spilanthol, saanshool-I, saanshool-II, sanshoamide, Piper nigrum, Zanthoxylum peperitum, chavicine and piperine.

5. The anti-dandruff composition of claim 2 wherein the cooling sensate enhancer is selected from the group consisting of Jambu oleoresin, Spilanthol, saanshool-I, saanshool-II, sanshoamide, Piper nigrum, Zanthoxylum peperitum, chavicine and piperine.

6. The anti-dandruff composition of claim 1 wherein the weight ratio of anti-dandruff agent:

cooling sensate material;

cooling sensate enhancer material is in the range of from about 0.7 to about 1.5 antidandruff agent;

from about 0.5 to about 1.5 cooling sensate material;

from about 0.001 up to about 0.1 cooling sensate enhancer.

7. The anti-dandruff composition of claim 6 wherein the weight ratio of cooling sensate material:

cooling sensate enhancer material is from about 1;

0.1 to about 1;

0.01.

8. The anti-dandruff composition of claim 1 wherein the anti-dandruff agent is the zinc salt of 1-hydroxy-2-pyridinethione;

the cooling sensate material comprises menthol; and

the cooling sensate enhancer comprises n-nonylic acid vanillamide.

9. The antidandruff composition of claim 1 wherein the cooling sensate material is a mixture of menthol and 2-isopropyl-N,2,3-trimethylbutyramide and the cooling sensate enhancer is vanillyl-n-butyl ether.

10. The anti-dandruff composition of claim 1 wherein the cooling sensate material comprises menthol and the cooling sensate enhancer is Jambu oleoresin.

11. The anti-dandruff composition of claim 10 wherein the cooling sensate material is a mixture of menthol and 2-isopropyl-N,2,3-trimethylbutyramide.

12. An anti-dandruff shampoo comprising water, a shampoo base and the anti-dandruff composition of claim 1.

13. The anti-dandruff shampoo of claim 12 wherein the weight percent of anti-dandruff composition is from about 0.5% to about 2.5% by weight of the shampoo.

14. The anti-dandruff shampoo of claim 12 additionally comprising a fragrance, each of the components of which has a C log₁₀P (i) in the range of from about 1 up to about 3, without restriction on the molecular weight of each of said components, (ii) in the range of from about greater than 3 up to about 10 for components each of which has a molecular weight in the range of from about 120 up to about 350 or (iii)in the range of from about 1 up to about 3, without restriction on the molecular weight of each of said components and in the range of from about greater than 3 up to about 10 for components each of which has a molecular weight in the range of from about 120 up to about 350, wherein P is the n-octanol/water partition coefficient of the fragrance component.

15. A method for reducing pruritis of the mammalian scalp caused by seborrheic dermatitis comprising the steps of (i) applying to said mammalian scalp a pruritis reducing quantity and concentration of the shampoo of claim 12 for a pruritis reducing period of time and (ii) applying to said mammalian scalp a rinsing quantity of water in order to remove residual shampoo.

16. The method of claim 15 wherein application of the shampoo to the mammalian scalp also exerts at least one of:

i. a substantial soothing effect;

ii. a deep-cleansed effect as measured by the IFF squeak test;

iii. a significant itch reduction;

iv. a substantial tingling effect;

v. a substantial warming effect;

vi. a substantial cooling effect;

or

vii. a significantly enhanced “

menthol/medicinal”

aroma.

20. The anti-dandruff composition of claim 3 wherein the cooling sensate material is N-ethyl-p-menthane-3-carboxamide.

17. An composition for reducing an itch sensation occurring on the outer surface of the mammalian epidermis comprising:

(a) an anti-itch agent;

(b) a cooling sensate material; and

(c) a cooling sensate enhancer.

18. The anti-itch composition of claim 17 wherein the cooling sensate enhancer material is selected from the group consisting of a vanillyl C₂-C₈ alkyl ether, a menthoxymethyl dihydroxyphenyl dioxolane, a menthoxymethyl hydroxymethoxyphenyl dioxolane, a C₇-C₁₂ alkanoic acid vanillamide, a vanillin or ethyl vanillin C₃-C₆ alkylene glycol acetal, ginger oleoresin, capsicum oleoresin, capsaicin, Jambu oleoresin, Spilanthol, saanshool-I, saanshool-II, sanshoamide, Piper nigrum, Zanthoxylum peperitum, chavicine and piperine.

19. The anti-itch composition of claim 18 wherein the cooling sensate material is N-ethyl-p-menthane-3-carboxamide.

21. A personal care composition comprising a personal care composition base and admixed therewith the anti-itch composition of claim 17.

22. The personal care composition of claim 21 wherein the personal care composition base is selected from the group consisting of a shampoo base, an ointment base, a soap base and a cream base.

23. A method for reducing an itch sensation occurring on the outer surface of the mammalian epidermis comprising the step of applying to the mammalian epidermis an itch-reducing quantity and concentration of the personal care composition of claim 21.