Injectable bone mineral substitute material

• US 20030161858A1
• Filed: 03/11/2003
• Published: 08/28/2003
• Est. Priority Date: 04/11/2000
• Status: Active Grant

• Current Assignee: BONE Support NYA AB
• Original Assignee: BONE Support NYA AB
• Inventors: Lidgren, Lars
• Granted Patent: US 7,972,630 B2
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/428 Vitamins, e.g. tocopherol, riboflavin
• CPC Class Codes: A61L 2300/43 Hormones, e.g. dexamethasone
• CPC Class Codes: A61L 24/0005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/3637 characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 for osteoporosis

Abstract

An injectable bone mineral substitute material composition comprises an inorganic bone cement powder and a biologically compatible oil. The oil is an intermixture with the cement powder at a concentration of less than 10 wt % of the total weight of the composition in order to improve the rheology of the same. In a method of intermixing a powder of an implant material and a biologically compatible oil to a composition the oil is mixed with the powder of implant material at an elevated temperature.

Claims

1. An injectable bone mineral substitute material composition comprising an inorganic bone cement powder and a biologically compatible oil, characterized in that the oil is a intermixture with the cement powder at a concentration of less than 10 wt % of the total weight of the composition in order to improve the rheology of the composition.

2. A composition as in claim 1, characterized in that a biologically active substance is dissolved, dispersed or emulsified in the biologically compatible oil to be released therefrom, after hardening of the composition to a bone mineral substitute, over a period of time.

3. A composition as in claim 2, characterized in that the biologically active substance is an antioxidant, a vitamin, a hormone, an antibiotic, a cytostatic, a bisphosphonate, a growth factor, or a protein, alone or in combination.

4. A composition as in claim 2 or 3, characterized in that the antioxidant and the biologically compatible oil is a vitamin E.

5. A composition as in claim 4, characterized in that the vitamin E is α

-tocopherol.

6. A composition as in claim 3 characterized in that the hormone is oxytocin.

7. A composition as in claim 3, characterized in that the hormone is a growth hormone.

8. A composition as in any of claims 2-7, characterized in that the biologically active substance comprises 0.05-10 wt % of the hardened bone mineral substitute material.

9. A composition as in any of claims 1-3, characterized in that the biologically compatible oil is cotton seed oil, linseed oil, sunflower oil, olive oil, soybean oil, maize oil, almond oil, peanut oil, palm oil, whale oil, or bone oil, alone or in combination.

10. A composition as in any of claims 1-9, characterized in that the cement powder is a calcium sulphate powder, a hydroxylapatite powder, or a calcium phosphate powder, alone or in combination.

11. A bone mineral substitute prepared from the composition as in any of claims 1-10, characterized in that it is hardened pellets, small beads, rods, or blocks.

12. A bone mineral substitute as in claim 11, characterized in that it is threaded on a string of a non-bioresorbable or bioresorbable material.

13. A bone mineral substitute as in claim 12, characterized in that the bioresorbable material is polylactide or polyglycol.

14. A method of intermixing a powder of an implant material and a biologically compatible oil to a composition, the oil comprising less than 10 wt % of the total weight of the composition, characterized in that the oil is mixed with the powder of implant material at a temperature between 30°

C. and 120°

C.

15. A method as in claim 14, characterized in that the oil is mixed with the powder of implant material at a temperature between 50°

C. and 90°

C.

16. A method as in claim 14 or 15, characterized in that the oil is mixed with the powder of implant material by means of rolling.