Percutaneous absorption system and percutaneous absorption method

• US 20030161869A1
• Filed: 02/26/2003
• Published: 08/28/2003
• Est. Priority Date: 02/28/2002
• Status: Active Grant

• Current Assignee: Kenji Sugibayashi, Lintec Corporation
• Original Assignee: Lintec Corporation
• Inventors: Nakagawa, Kiyose, Saito, Rui, Hatanaka, Tomio, Sugibayashi, Kenji
• Granted Patent: US 7,858,112 B2
• Time in Patent Office: Days
• US Class Current: 424/449
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

The present invention provides a percutaneous absorption system and a percutaneous absorption method, which have a simple constitution and can realize the easy and continuous percutaneous absorption of medicine even when the medicine is formed of a water-soluble oligomer solution or a high-molecular solution. In the percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine therein and a support portion for supporting the medicine reservoir portion, the support portion including an adhesive layer and a substrate having medicine non-permeating property, the system is provided with an elastic member for applying pressure to the medicine held in the inside of the medicine reservoir portion, and by breaking the substrate having medicine non-permeating property in the support portion using a mechanical stimulus such as an injection needle or the like, the medicine is released(delivered) at a fixed rate.

Claims

1. A percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine therein and a support portion for supporting the medicine reservoir portion, the support portion including an adhesive layer and a substrate having medicine non-permeating property, wherein

a portion or the whole of the medicine reservoir portion is constituted of a elastic member for applying pressure to the medicine held in the medicine holding portion, and the substrate having medicine non-permeating property in the support portion is breakable upon receiving a mechanical stimulus.

2. The percutaneous absorption system according to claim 1, wherein the mechanical stimulus is a mechanical stimulus given from the outside of the percutaneous absorption system.

3. The percutaneous absorption system according to claim 1, wherein the mechanical stimulus is a mechanical stimulus given by a projection provided in the inside of the medicine reservoir portion.

4. The percutaneous absorption system according to claim 1, wherein the elastic member is a foamed body.

5. The percutaneous absorption system according to claim 1, wherein the medicine reservoir portion has a substantially cylindrical shape and defines the medicine holding portion in the inside thereof.

6. The percutaneous absorption system according to claim 3, wherein the projection has a distal end portion thereof extended downwardly and arranged substantially in the direction perpendicular to the substrate having medicine non-permeating property.

7. The percutaneous absorption system according to claim 3, wherein the projection is mounted on an upper surface of the medicine reservoir portion and the upper surface of the medicine reservoir portion is formed of an elastic member.

8. The percutaneous absorption system according to claim 3, wherein a pushing portion which is served for pushing down the projection is formed on an end portion of the projection.

9. A percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine therein and a support portion for supporting the medicine reservoir portion, the support portion including an adhesive layer and a substrate having medicine non-permeating property, wherein

bubbles which apply pressure to the medicine held in the medicine holding portion are introduced in the inside of the medicine holding portion and the substrate having medicine non-permeating property in the support portion is breakable upon receiving a mechanical stimulus.

10. The percutaneous absorption system according to claim 9, wherein a portion or the whole of the medicine reservoir portion is constituted of an elastic member for applying pressure to the medicine held in the medicine holding portion.

11. A percutaneous absorption method which uses a percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine therein and a support portion for supporting the medicine reservoir portion, the support portion including an adhesive layer and a substrate having medicine non-permeating property, wherein

the method comprises a step for mounting the percutaneous absorption system, a step for breaking at least the substrate having medicine non-permeating property in the support portion using a mechanical stimulus, and a step for delivering the medicine by applying pressure to the medicine using an elastic member provided to the medicine reservoir portion.

12. A percutaneous absorption method which uses a percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine therein and a support portion for supporting the medicine reservoir portion, the support portion including an adhesive layer and a substrate having medicine non-permeating property, wherein

the method comprises a step for mounting the percutaneous absorption system, a step for breaking at least the substrate having medicine non-permeating property in the support portion using a mechanical stimulus, and a step for delivering the medicine by applying pressure to the medicine using bubbles introduced into the medicine reservoir portion.