Orthogonal read assembly
First Claim
1. An orthogonal read assembly, comprising:
- an immunoassay reaction chamber;
a read cell comprising a lumen in fluid communication with said immunoassay reaction chamber;
a transmitter configured to transmit energy through said lumen; and
a detector configured to sense energy emitted transversely from said lumen.
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Abstract
Methods and assemblies are provided for transmitting and detecting energy within a read cell. An orthogonal read assembly includes an immunoassay reaction chamber, a read cell having a lumen in fluid communication with the immunoassay reaction chamber, a transmitter configured to transmit energy through the lumen, and a detector configured to sense energy emitted transversely from the lumen. The transmitter can include an optical transmitter, such as a laser, and the detector can include an optical detector, e.g., a silicon diode. The optical transmitter can transmit optical energy at an oblique entry angle to the lumen, e.g., 45°, and the optical energy can be sensed by the optical detector at an angle substantially perpendicular to the lumen. The read cell can be composed of a transparent plastic and can be parallel-pipe shaped. The lumen can be cylindrically shaped and may include an optical transmission port, in which case, the optical transmitter can be configured to transmit the optical energy through the lumen via the optical transmission port.
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Citations
35 Claims
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1. An orthogonal read assembly, comprising:
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an immunoassay reaction chamber;
a read cell comprising a lumen in fluid communication with said immunoassay reaction chamber;
a transmitter configured to transmit energy through said lumen; and
a detector configured to sense energy emitted transversely from said lumen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An orthogonal read assembly, comprising:
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an immunoassay reaction chamber containing labeled antigen that is displaced when an analog to said labeled antigen flows through said immunoassay reaction chamber;
a read cell comprising a lumen in fluid communication with said immunoassay reaction chamber;
a transmitter configured to transmit energy through said lumen to excite said labeled antigen to transversely emit energy from said lumen; and
a detector configured to sense said transversely emitted energy from said labeled antigen. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method of sensing an analyte within a sample, comprising:
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flowing said sample through an immunoassay reaction chamber to displace labeled antigen from said immunoassay reaction chamber;
flowing said displaced labeled antigen through a lumen of a read cell;
transmitting energy along a longitudinal axis of said lumen to excite said displaced labeled antigen into transversely emitting energy from said lumen; and
sensing said transversely emitted energy. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35)
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Specification