Biomedical devices containing internal wetting agents
First Claim
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1. A biomedical device formed from a reaction mixture comprising a high molecular weight hydrophilic polymer and an effective amount of an hydroxyl-functionalized silicone-containing monomer.
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Abstract
This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.
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Citations
162 Claims
- 1. A biomedical device formed from a reaction mixture comprising a high molecular weight hydrophilic polymer and an effective amount of an hydroxyl-functionalized silicone-containing monomer.
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13. A method of preparing a biomedical device comprising mixing a high molecular weight hydrophilic polymer and an effective amount of a hydroxyl-functionalized silicone-containing monomer to form a clear solution, and curing said solution.
- 14. A silicone hydrogel formed from a reaction mixture comprising a high molecular weight hydrophilic polymer and an effective amount of an hydroxyl-functionalized silicone-containing monomer.
- 66. A method comprising the steps of (a) mixing reactive components comprising at least one high molecular weight hydrophilic polymer and an effective amount of at least one hydroxyl-functionalized silicone-containing monomer and (b) curing the product of step (a) to form a biomedical device.
- 93. The method of claim 93 wherein said initiator comprises bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide.
- 123. A method comprising the steps of (a) mixing reactive components comprising a high molecular weight hydrophilic polymer and an effective amount of a hydroxyl-functionalized silicone containing monomer and (b) curing the product of step (a) at or above a minimum gel time, to form a wettable biomedical device.
- 136. An ophthalmic device comprising at least one hydroxyl-functionalized silicone-containing monomer and an amount of high molecular weight hydrophilic polymer sufficient to provide said device, without a surface treatment, with an advancing dynamic contact angle of less than about 80°
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137. An ophthalmic device comprising at least one hydroxyl-functionalized silicone-containing monomer and an amount of high molecular weight hydrophilic polymer sufficient to provide said device, without a surface treatment, with an advancing dynamic contact angle which is at least about 10% lower than an advancing dynamic contact angle for an ophthalmic device which does not contain said hydrophilic polymer.
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138. An ophthalmic device comprising at least one hydroxyl-functionalized silicone-containing monomer and an amount of high molecular weight hydrophilic polymer sufficient to provide said device, without a surface treatment, with tear film break up time after about one day of wear of at least about 7 seconds.
- 152. A method for improving the wettability of an ophthalmic device formed from a reaction mixture comprising adding at least one high molecular weight hydrophilic polymer and an effective amount of at least one compatibilizing monomer to said reaction mixture.
- 156. A method for improving the wettability of an ophthalmic device formed from a reaction mixture comprising incorporating at least one high molecular weight hydrophilic polymer and an effective amount of at least one hydroxyl-functionalized silicone containing monomer to said reaction mixture.
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162. A device comprising a silicone hydrogel contact lens which is substantially free from surface deposition without surface modification.
Specification