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Selective enzymatic esterification and solvolysis of epimeric vitamin D analog and separation of the epimers

  • US 20030166226A1
  • Filed: 01/09/2003
  • Published: 09/04/2003
  • Est. Priority Date: 01/10/2002
  • Status: Active Grant
First Claim
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1. A method of selectively enzymatically esterifying the C-24 hydroxyl group of one epimer in a mixture of epimers of a vitamin D analog having a hydroxyl group at the stereogenic C-24 position thereof, comprising the steps of:

  • a) providing a solution of mixed C-24 epimers of a vitamin D analog having a hydroxyl group at the C-24 position thereof and an esterifying agent in an organic solvent, and b) contacting the solution with a lipase.

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