Compositions for sustained action product delivery and methods of use thereof
First Claim
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1. A pharmaceutical composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a bioactive agent and having a geometric diameter of about 1 micron or less.
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Abstract
The present invention features pharmaceutical compositions comprising nanoparticles containing a sustained release bioactive agent, method of making such compositions, and method of therapy using such compositions.
130 Citations
125 Claims
- 1. A pharmaceutical composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a bioactive agent and having a geometric diameter of about 1 micron or less.
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36. A pharmaceutical composition comprising phospholipid-containing biodegradable particles, said particles having a geometric diameter of between about 4 microns and about 8 microns and an aerodynamic diameter of between about 1 micron and about 3 microns, said particles comprising between about 5% and about 80% by weight nanoparticles, said nanoparticles having a geometric diameter of between about 25 nanometers and about 1 micron, and wherein said nanoparticles are carboxylate modified polystyrene beads.
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37. A pharmaceutical composition comprising phospholipid-containing biodegradable particles, said particles having a geometric diameter of between about 5 microns and about 8 microns and an aerodynamic diameter of between about 2.5 and about 3.5, said particles comprising between about 5% and about 70% by weight nanoparticles, said nanoparticles having a geometric diameter of between about 25 nanometers and about 1 micron, and wherein said nanoparticles are carboxylate modified polystyrene beads.
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38. A pharmaceutical composition comprising phospholipid-containing biodegradable particles, said particles having a geometric diameter of between about 8 microns and about 12.5 microns and an aerodynamic diameter of between about 2 microns and about 3 microns, said particles comprising between about 5 and about 85% by weight nanoparticles, said nanoparticles having a geometric diameter of between about 25 nanometers and about 1 micron, and wherein said nanoparticles are carboxylate modified polystyrene beads.
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39. A pharmaceutical composition comprising phospholipid-containing biodegradable particles, said particles having a geometric diameter of between about 7.5 microns and about 15 microns and an aerodynamic diameter of between about 4.5 and about 7.5, said particles comprising between 5 and 90% by weight nanoparticles, said nanoparticles having a geometric diameter of between about 25 nanometers and about 1 micron, and wherein said nanoparticles are colloidal silica.
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40. A pharmaceutical composition comprising phospholipid-containing biodegradable particles and nanoparticles, wherein said nanoparticles comprise Rifampicin and one or more phospholipids.
- 41. A method of treating a condition in a patient, comprising the step of administering to said patient a pharmaceutical composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a bioactive agent and having a geometric diameter of about 1 micron or less.
- 79. A method of making spray dried particles comprising sustained action nanoparticles, said nanoparticles comprising a bioactive agent and having a geometric diameter of about 1 micron or less, said method comprising the steps of spray drying a solution comprising said nanoparticles or reagents capable of forming nanoparticles under conditions that form spray dried particles.
- 115. A composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a nutraceutical agent and having a geometric diameter of about 1 micron or less.
- 124. A method of treating a nutritional deficiency in a patient comprising the step of administering to said patient a composition comprising spray dried particles, said particles comprising sustained action nanoparticles, said nanoparticles comprising a nutraceutical agent and having a geometric diameter of about 1 micron or less.
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