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Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules

  • US 20030170202A1
  • Filed: 12/18/2002
  • Published: 09/11/2003
  • Est. Priority Date: 04/23/1999
  • Status: Abandoned Application
First Claim
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1. A polymer having a structure selected from the group consisting of:

  • R(—

    O—

    R1), and R(—

    NH—

    R1)x wherein R(—

    O—

    )x is a polyol moiety and R(—

    NH)x is a polyamine moiety, with x being between 2 and 10, inclusive, and each R1 independently has the structure;

    wherein

    is a divalent amino acid moiety with R2 being a covalent bond or having from 1 to 8 carbon atoms, and y and z are between 0 and 10, inclusive, provided that y and z are not both 0;

    wherein

    is a divalent dicarboxylic acid moiety in which R3 is an alkylene or cycloalkylene group containing from 1 to about 15 carbon atoms, substituted with a total of from 1 to about 10 hydroxyl groups, with at least a portion of the hydroxyl groups being acylated with from 3 to about 24 carbon atom carboxylic acids; and

    wherein R4 is a poly(alkylene oxide) having the structure;

    R5

    (R6

    O—

    )a

    R6-Q- with R5 being selected from the group consisting of 1 to 40 carbon atom alkyl groups, —

    OH, —

    OR7, —

    NH2, —

    NHR7, —

    NHR7R8, —

    C—

    OH, —

    C—

    OR7, —

    C—

    O—

    C—

    R7, —

    C—

    NH2, —

    C—

    NHR7 and —

    C—

    NR7R8;

    R6, R7 and R8 being independently selected from the group consisting of 2 to 40 carbon atom, straight-chain or branched alkylene groups;

    Q being a divalent linkage moiety; and

    a being between 2 and 110, inclusive;

    with the proviso that when y is 0 and R is a 1,1,1-tris(hydroxyphenyl)ethane moiety, the divalent dicarboxylic acid moiety is not an acylated mucic acid moiety.

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