Nitric oxide synthase gene diagnostic polymorphisms
First Claim
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1. A method for diagnosing a genetic predisposition for a disease, condition or disorder in a subject comprising, obtaining a biological sample containing nucleic acid from said subject;
- and analyzing said nucleic acid to detect the presence or absence of a single nucleotide polymorphism in SEQ ID NO;
1 or the complement thereof, wherein said single nucleotide polymorphism is associated with a genetic predisposition for a disease selected from the group consisting of hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, and end stage renal disease due to non-insulin dependent diabetes mellitus.
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Abstract
Disclosed is a method for determining a genetic predisposition to hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, end stage renal disease due to non-insulin dependent diabetes mellitus, breast cancer, lung cancer or prostate cancer by detecting the presence or absence of single nucleotide polymorphisms in the nitric oxide synthase gene. Also disclosed are kits for detecting the presence or absence of the single nucleotide polymorphisms, methods for the treatment and/or prophylaxis of diseases, conditions, or disorders associated with the single nucleotide polymorphisms.
29 Citations
31 Claims
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1. A method for diagnosing a genetic predisposition for a disease, condition or disorder in a subject comprising, obtaining a biological sample containing nucleic acid from said subject;
- and analyzing said nucleic acid to detect the presence or absence of a single nucleotide polymorphism in SEQ ID NO;
1 or the complement thereof, wherein said single nucleotide polymorphism is associated with a genetic predisposition for a disease selected from the group consisting of hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, and end stage renal disease due to non-insulin dependent diabetes mellitus. - View Dependent Claims (2, 3, 4, 5)
- and analyzing said nucleic acid to detect the presence or absence of a single nucleotide polymorphism in SEQ ID NO;
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6. A method for diagnosing a genetic predisposition for a disease, condition or disorder in a subject comprising, obtaining a biological sample containing nucleic acid from said subject;
- and analyzing said nucleic acid to detect the presence or absence of a single nucleotide polymorphism in SEQ ID NO;
1 or the complement thereof, wherein said single nucleotide polymorphism is associated with a genetic predisposition for a disease selected from the group consisting of hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, end stage renal disease due to non-insulin dependent diabetes mellitus, breast cancer, lung cancer and prostate cancer. - View Dependent Claims (7, 8, 9)
- and analyzing said nucleic acid to detect the presence or absence of a single nucleotide polymorphism in SEQ ID NO;
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10. An isolated polynucleotide comprising at least 10 contiguous nucleotides of SEQ ID NO:
- 1 or the complement thereof, and containing at least one single nucleotide polymorphism at position 2548, 2575, 1272, 2841, 2843 or 3556 of SEQ ID NO;
1, wherein said at least one single nucleotide polymorphism is associated with a disease selected from the group consisting of hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, end stage renal disease due to non-insulin dependent diabetes mellitus, breast cancer, lung cancer and prostate cancer. - View Dependent Claims (11, 12, 13, 14)
- 1 or the complement thereof, and containing at least one single nucleotide polymorphism at position 2548, 2575, 1272, 2841, 2843 or 3556 of SEQ ID NO;
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15. A kit comprising at least one isolated polynucleotide of at least 10 continuous nucleotides of SEQ ID NO:
- 1 or the complement thereof, and containing at least one single nucleotide polymorphism associated with a disease, condition or disorder selected from the group consisting of hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, end stage renal disease due to non-insulin dependent diabetes mellitus, breast cancer, lung cancer and prostate cancer; and
instructions for using said polynucleotide for detecting the presence or absence of said single nucleotide polymorphism in said nucleic acid. - View Dependent Claims (16, 17, 18, 19, 20)
- 1 or the complement thereof, and containing at least one single nucleotide polymorphism associated with a disease, condition or disorder selected from the group consisting of hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, end stage renal disease due to non-insulin dependent diabetes mellitus, breast cancer, lung cancer and prostate cancer; and
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21. A kit comprising at least one polynucleotide of at least 10 contiguous nucleotides of SEQ ID NO:
- 1 or the complement thereof, wherein the 3′
end of said polynucleotide is immediately 5′
to a single nucleotide polymorphism site associated with a genetic predisposition to disease condition, or disorder selected from the group consisting of hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, end stage renal disease due to non-insulin dependent diabetes mellitus, breast cancer, lung cancer and prostate cancer; and
instructions for using said polynucleotide for detecting the presence or absence of said single nucleotide polymorphism in a biological sample containing nucleic acid. - View Dependent Claims (22, 23, 24)
- 1 or the complement thereof, wherein the 3′
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25. A method for treatment or prophylaxis in a subject comprising, obtaining a sample of biological material containing nucleic acid from a subject;
- analyzing said nucleic acid to detect the presence or absence of at least one single nucleotide polymorphism in SEQ ID NO;
1 or the complement thereof associated with a disease, condition or disorder selected from the group consisting of hypertension, end stage renal disease due to hypertension, non-insulin dependent diabetes mellitus, end stage renal disease due to non-insulin dependent diabetes mellitus, breast cancer, lung cancer and prostate cancer; and
treating said subject for said disease, condition or disorder. - View Dependent Claims (26, 27, 28, 29, 30, 31)
- analyzing said nucleic acid to detect the presence or absence of at least one single nucleotide polymorphism in SEQ ID NO;
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Current AssigneeViral Therapeutics, Inc. (Vybion, Inc.)
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Original AssigneeDZ Genes LLC
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InventorsMoskowitz, David W.
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Application NumberUS10/268,311Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current435/6CPC Class CodesC12Q 1/6883 for diseases caused by alte...C12Q 2600/156 Polymorphic or mutational m...
