Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
First Claim
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1. An oligonucleotide comprising between about 10 and 100 bases, wherein at least 2 of said bases are juxtaposed universal bases.
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Abstract
Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease.
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Citations
33 Claims
- 1. An oligonucleotide comprising between about 10 and 100 bases, wherein at least 2 of said bases are juxtaposed universal bases.
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17. An oligonucleotide comprising the formula:
XRY wherein X comprises between about 5 and 20 modified nucleic acid bases;
wherein R comprises between about 3 and 10 juxtaposed universal bases;
wherein Y comprises between about 5 and about 20 nucleic acid bases;
wherein X, R, and Y are covalently joined; and
wherein more than about 20% of the total number of bases in said oligonucleotide are said juxtaposed universal bases. - View Dependent Claims (18)
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20. A method for detecting a polymorphism in a sample of genetic material, comprising:
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providing an oligonucleotide comprising between about 10 and 100 bases, wherein at least 2 of said bases are juxtaposed universal bases;
contacting said genetic material with said oligonucleotide; and
identifying whether said oligonucleotide is bound to said genetic material, wherein said universal or generic bases are not located at the site or sites of said polymorphism. - View Dependent Claims (21, 22, 23, 24, 25)
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26. A method for diagnosing a genetic disease in a patient, comprising:
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providing an oligonucleotide specific for a DNA sequence related to said disease, wherein said oligonucleotide comprises between about 10 and 100 bases, and wherein at least 2 of said bases are juxtaposed universal bases;
contacting genetic material from said patient with said oligonucleotide; and
identifying whether said oligonucleotide is bound to said genetic material, wherein binding of said oligonucleotide to said genetic material is indicative of said genetic disease. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33)
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Specification